{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:21:31Z","timestamp":1787797291784,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T00:00:00Z","timestamp":1550448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Wuxi Children's Hospital"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The prevalence of <jats:italic>Candida<\/jats:italic> infections in paediatric intensive care units (<jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>s) has dramatically increased as a result of resistance to conventional anti\u2010fungal treatments. Because vitamin D has been shown to exhibit fungicidal activity against <jats:italic>Candida<\/jats:italic> infection in an <jats:italic>in\u00a0vitro<\/jats:italic> antimicrobial screening, we aimed to investigate the effect of vitamin D on <jats:italic>Candida<\/jats:italic> infections in the <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred sixteen eligible children aged between 12\u00a0months to 5\u00a0years old admitted to the <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content>, who were on broad\u2010spectrum antibiotic therapy, participated in the study. Patients were randomly assigned to two study groups, receiving a plain yogurt drink (placebo group) or supplemented with 300\u00a0<jats:styled-content style=\"fixed-case\">IU<\/jats:styled-content>\u00a0day<jats:sup>\u22121<\/jats:sup> vitamin D (<jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> group). Primary outcome was defined as the incidences of <jats:italic>Candida<\/jats:italic> colonisation (<jats:italic>Candida<\/jats:italic> isolated from rectal swab) 14\u00a0days after enrollment. Secondary outcome measures were <jats:italic>Candida<\/jats:italic> growth in blood (candidaemia) and urine (candiduria).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of candiduria as well as candidaemia was significantly lower in the <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content>\u2010treated group (26 cases) than in the placebo group (62 cases). The mean (SD) length of <jats:styled-content style=\"fixed-case\">PICU<\/jats:styled-content> stay was obviously lowered in the <jats:styled-content style=\"fixed-case\">VD<\/jats:styled-content> group [11.8\u00a0(1.2)\u00a0days] compared to the placebo group [15.2\u00a0(2.3\u00a0days)], whereas cases of patient death were similar between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Supplementation of vitamin D effectively reduces infections of <jats:italic>Candida<\/jats:italic> in children who were critically ill and on broad\u2010spectrum antibiotic treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12634","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T08:29:21Z","timestamp":1550478561000},"page":"512-517","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D\u2010supplemented yogurt drink reduces <i>Candida<\/i> 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