{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:41:06Z","timestamp":1783953666080,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["487564"],"award-info":[{"award-number":["487564"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Mexico, 80% women with cervical cancer are diagnosed at locally advanced stages and are treated with concomitant chemoradiotherapy. The treatment modality and catabolic state confer a nutritional risk. The present study aimed to thoroughly evaluate the nutritional status and change in body composition of locally advanced cervical cancer (<jats:styled-content style=\"fixed-case\">LACC<\/jats:styled-content>) patients throughout treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An observational prospective study, carried out at the Mexican National Cancer Institute, included 55 <jats:styled-content style=\"fixed-case\">LACC<\/jats:styled-content> patients. Nutritional status was evaluated before, during and after treatment, using anthropometric, dietary and biochemical measurements. Body composition was analysed using computed tomography images obtained at the time of diagnosis and approximately 4\u00a0months after treatment completion. Clinical outcomes were associated with changes in body composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the time of diagnosis, no patients were clinically malnourished, although 33.3% presented sarcopenia and most were overweight; by the end of treatment, 69% became clinically malnourished and 58% were sarcopenic. Average weight loss was 7.4\u00a0kg (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Adequacy of energy intake was reduced to 54%, obtained predominantly from carbohydrates. By the week 9, 62.8% patients became anemic and 34.5% had low albumin levels. Body composition analysis revealed that patients lost both, muscle and adipose tissues, although 27% patients were muscle depleted by the end of treatment. Patients who lost \u226510% skeletal muscle presented a higher tumour recurrence (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content>\u00a0=\u00a02.957, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and a tendency towards diminished overall survival (<jats:styled-content style=\"fixed-case\">hazard ratio<\/jats:styled-content>\u00a0=\u00a02.572, not significant).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The nutritional status of cervical cancer patients deteriorates during treatment with concomitant chemoradiotherapy and, most importantly, muscle loss impacts the clinical outcome of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12649","type":"journal-article","created":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T04:45:51Z","timestamp":1554180351000},"page":"480-491","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Deterioration of nutritional status of patients with locally advanced cervical cancer during treatment with concomitant chemoradiotherapy"],"prefix":"10.1111","volume":"32","author":[{"given":"M.","family":"S\u00e1nchez","sequence":"first","affiliation":[{"name":"Department of Gynecology\u2010Oncology Instituto Nacional de Cancerolog\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6873-122X","authenticated-orcid":false,"given":"D.","family":"Castro\u2010Eguiluz","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda (CONACYT)\u2010 Department of Clinical Research Instituto Nacional de Cancerolog\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Luvi\u00e1n\u2010Morales","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Instituto Nacional de Cancerolog\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Jim\u00e9nez\u2010Lima","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Instituto Nacional de Cancerolog\u00eda Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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