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Osteogenesis imperfecta (<jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>) is a collagen disorder with a range of symptoms, ranging from fractures to minimum trauma, and it is typically treated with bisphosphonates. In the present study, we evaluate the impact of a nutritional intervention (<jats:styled-content style=\"fixed-case\">NI<\/jats:styled-content>) on dietary calcium intake and bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>) in paediatric patients with <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A nonrandomised clinical trial was designed with a <jats:styled-content style=\"fixed-case\">NI<\/jats:styled-content>. Dietary calcium intake, anthropometry and clinical features were assessed at baseline, including anthropometry, basal metabolic rate (<jats:styled-content style=\"fixed-case\">BMR<\/jats:styled-content>), <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. In addition, a food guidance form was developed and sent to patients by mail. After 12\u00a0months, clinical features of patients were reassessed and compared with the baseline data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010two children and adolescents were enrolled. Significant increases in total calcium intake (mg day<jats:sup>\u22121<\/jats:sup>), percentage of adequate calcium intake (%) and number of cups of milk ingested were observed after <jats:styled-content style=\"fixed-case\">NI<\/jats:styled-content>. We detected a positive correlation between the variation of <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> and milk consumption in patients treated with bisphosphonate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed an increase in calcium intake in patients with <jats:styled-content style=\"fixed-case\">OI<\/jats:styled-content>. This finding demonstrates the importance of nutrition therapy as part of a multidisciplinary treatment approach for bone health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12657","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T01:41:38Z","timestamp":1556674898000},"page":"619-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Calcium intake improvement after nutritional intervention in paediatric patients with osteogenesis imperfecta"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4575-4418","authenticated-orcid":false,"given":"M. B.","family":"Zambrano","sequence":"first","affiliation":[{"name":"Post Graduate Program in Child and Adolescent Health University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. M.","family":"F\u00e9lix","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Child and Adolescent Health University of Rio Grande do Sul Porto Alegre Brazil"},{"name":"Medical Genetics Service Hospital de Clinicas de Porto Alegre Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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