{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:58:25Z","timestamp":1787727505316,"version":"build-2784847793"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Over 30% of the population of Okinawa Prefecture have a high body mass index. The incidence of hypertension and dyslipidaemia has also increased in recent years. We found that Ooitabi (<jats:italic>Ficus pumila<\/jats:italic> L.), a plant native to Okinawa, was useful for hypertension. During ancient times, the extracts of Ooitabi leaves were used for making Ishimaki tea in some areas of Okinawa Prefecture. The plants in Okinawa are rich in antioxidants, and four flavonoid glycosides, including rutin, have been identified in Ooitabi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, we conducted clinical verification tests on the effects of drinking Ishimaki tea on outpatients with hypertension and dyslipidaemia. Of 3814 Japanese patients who underwent medical check\u2010ups in Okinawa, 38 individuals with high blood pressure, dyslipidaemia, liver dysfunction and gout visited our hospital as outpatients and were asked to drink Ishimaki tea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3\u00a0months, there were significant reductions in body mass index, systolic and diastolic blood pressure, total cholesterol, low\u2010density lipoprotein cholesterol, \u03b3\u2010glutamyltrans peptidase, uric acid and ratio of blood vessel insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ooitabi extract can lower blood pressure and improve lipid abnormalities and has likely contributed to the well\u2010known health and longevity of the population in Okinawa.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12806","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T23:52:47Z","timestamp":1598485967000},"page":"395-401","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Potential curing and beneficial effects of Ooitabi (<i>Ficus pumila<\/i> L.) on hypertension and dyslipidaemia in Okinawa"],"prefix":"10.1111","volume":"34","author":[{"given":"K.","family":"Suzuki","sequence":"first","affiliation":[{"name":"Daido Obesity and Metabolism Research Center Naha Japan"},{"name":"Daido Central Hospital Naha Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-1808","authenticated-orcid":false,"given":"K.","family":"Gonda","sequence":"additional","affiliation":[{"name":"Daido Obesity and Metabolism Research Center Naha Japan"},{"name":"Daido Central Hospital Naha Japan"},{"name":"Department of Bioregulation and Pharmacological Medicine Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Executive Office of the Governor Okinawa Prefectural Government Naha Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Katsumoto","sequence":"additional","affiliation":[{"name":"Faculty of Science Fukuoka University Jonan Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Takenoshita","sequence":"additional","affiliation":[{"name":"Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329894"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-006-9020-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2014.01.002"},{"key":"e_1_2_8_5_1","first-page":"59","article-title":"Danshen: a phytochemical and pharmacological overview","volume":"17","author":"Me XD","year":"2019","journal-title":"Chin J Nat Med"},{"key":"e_1_2_8_6_1","unstructured":"Healthline.Nutrition. Available at:https:\/\/www.healthline.com\/nutrition\/okinawa\u2010diet"},{"key":"e_1_2_8_7_1","unstructured":"The Garden of Eaden(2016)HOW TO GROW FICUS PUMILA. Available at:https:\/\/gardenofeaden.blogspot.com\/2016\/12\/how\u2010to\u2010grow\u2010ficus\u2010pumila.html. (accessed February 2020)."},{"key":"e_1_2_8_8_1","unstructured":"VanZileJ. (2019)Growing Creeping Fig Indoors How to Grow and Care for Ficus Pumila. Available at:https:\/\/www.thespruce.com\/grow\u2010creeping\u2010fig\u2010indoors\u20101902441(accessed February 2020)."},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.12705\/646.12"},{"key":"e_1_2_8_10_1","first-page":"53","article-title":"Phytophotodermatitis caused by Ficus pumila","volume":"67","author":"Rademaker M","year":"2012","journal-title":"ContactDermatitis"},{"key":"e_1_2_8_11_1","unstructured":"A Singapore Government(2019)Ficus pumila L. \u2010 National Parks Board. FLORA and FAUNAWEB. A Singapore Government Agency Website. 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