{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T11:24:53Z","timestamp":1771586693098,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A 25\u2010hydroxyvitamin D (25OHD) may exert immunomodulatory effects on respiratory health, which may translate to improvements in exercise physiology. Thus, we aimed to investigate whether plasma 25OHD is associated with lung function and aerobic fitness in people with cystic fibrosis (pwCF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre retrospective review of pwCF (&gt;\u00a09\u00a0years old) attending the Royal Hospital for Sick Children (Edinburgh) or Wessex CF\u2010Unit (Southampton) was performed between July 2017 and October 2019. Demographic and clinical data were collected. Plasma 25OHD measured closest in time to clinical cardiopulmonary exercise testing and\/or spirometry [forced expiratory volume (FEV<jats:sub>1<\/jats:sub>)% predicted] was recorded. Pancreatic insufficiency was diagnosed based on faecal elastase of &lt;\u00a0100\u00a0\u00b5g g<jats:sup>\u22121<\/jats:sup>. We performed multiple\u2010regression analysis with aerobic fitness outcomes [peak oxygen uptake (VO<jats:sub>2\u00a0peak<\/jats:sub>)] and FEV<jats:sub>1<\/jats:sub>% predicted as primary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety pwCF [mean\u00a0\u00b1\u00a0SD age: 19.1\u00a0\u00b1\u00a08.6\u00a0years, 54 (60%) children, 48 (53%) males and 88 (98%) Caucasian] were included. 25OHD deficiency and insufficiency was 15 (17%) and 44 (49%), respectively. 25OHD deficiency and insufficiency was significantly associated with pancreatic insufficiency (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a04.8<jats:italic>, p<\/jats:italic>\u00a0=\u00a00.02). Plasma 25OHD was not significantly associated with FEV<jats:sub>1<\/jats:sub>% predicted (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.06, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.42, 95% CI\u00a0=\u00a0\u22120.09 to 0.19) or VO<jats:sub>2\u00a0peak<\/jats:sub> (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.04, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.07, 95% CI\u00a0=\u00a0\u2212011 to 0.005) in all pwCF. However, 25OHD was significantly associated with both FEV<jats:sub>1<\/jats:sub>% (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.15, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02, 95% CI\u00a0=\u00a01.99\u20132.64) and VO<jats:sub>2\u00a0peak<\/jats:sub> (<jats:italic>r<jats:sup>2<\/jats:sup><\/jats:italic>\u00a0=\u00a00.13, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.05, 95% CI\u00a0=\u00a0\u22120.26 to \u22120.005) in the paediatric cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We showed that 25OHD is associated with improved lung function and aerobic fitness in children and adolescents with CF. Mechanistic and high\u2010quality prospective studies including both lung function and aerobic fitness as primary outcomes are now warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.12906","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T08:49:07Z","timestamp":1619599747000},"page":"363-375","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The impact of plasma 25\u2010hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-7146","authenticated-orcid":false,"given":"Raquel","family":"Revuelta Iniesta","sequence":"first","affiliation":[{"name":"School of Sport and Health Sciences University of Exeter Exeter UK"},{"name":"Child Life and Health University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-4432","authenticated-orcid":false,"given":"Adam J.","family":"Causer","sequence":"additional","affiliation":[{"name":"Department for Health University of Bath Bath UK"},{"name":"Wessex Cystic Fibrosis Unit University Hospital Southampton Foundation NHS Trust Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irantzu","family":"Arregui\u2010Fresneda","sequence":"additional","affiliation":[{"name":"Wessex Cystic Fibrosis Unit University Hospital Southampton Foundation NHS Trust Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Connett","sequence":"additional","affiliation":[{"name":"National Institute for Health Research Southampton Biomedical Research Centre Southampton Children\u2019s Hospital Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark I.","family":"Allenby","sequence":"additional","affiliation":[{"name":"Wessex Cystic Fibrosis Unit University Hospital Southampton Foundation NHS Trust Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Daniels","sequence":"additional","affiliation":[{"name":"Wessex Cystic Fibrosis Unit University Hospital Southampton Foundation NHS Trust Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary P.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Wessex Cystic Fibrosis Unit University Hospital Southampton Foundation NHS Trust Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don S.","family":"Urquhart","sequence":"additional","affiliation":[{"name":"Department of Paediatric Respiratory and Sleep Medicine Royal Hospital for Sick Children Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe L.","family":"Saynor","sequence":"additional","affiliation":[{"name":"Wessex Cystic Fibrosis Unit University Hospital Southampton Foundation NHS Trust Southampton UK"},{"name":"School of Sport, Health and Exercise Sciences University of Portsmouth Portsmouth UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2017.03.006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2019.01.003"},{"key":"e_1_2_13_4_1","volume-title":"Cystic fibrosis: Diagnosis and protocols: Guidance and guidelines","author":"NICE","year":"2017"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.157.6.9712089"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2016.10.009"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5812\/asjsm.34736"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622310381934"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018816653357"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011\u20100385"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.022"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516004074"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2014.12.023"},{"key":"e_1_2_13_14_1","unstructured":"Caireen RobertsTS MaplethorpeN CoxL MeadowsS NicholsonS PageP et al.National Diet and Nutrition Survey Results from Years 7 and 8 (combined) of the Rolling Programme (2014\/2015 to 2015\/2016);2018.https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/699241\/NDNS_results_years_7_and_8.pdf. Accessed 20 June 2020."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00151"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201208\u2010068OC"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2014.12.006"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24460"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439057"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0101\u20102018"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201806\u20101110OC"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421\u2010018\u20104018\u20105"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00136.2016"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.09.014"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000586"},{"key":"e_1_2_13_26_1","unstructured":"FibrosisC.All about Nutrition. Vitamin supplements in Cystic Fibrosis.2019.http:\/\/www.cysticfibrosis.org.uk. Accessed 11\/10\/2020."},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2002.124829"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00130010"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0954\u20106111(05)80346\u20104"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00080312"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.48.8.794"},{"key":"e_1_2_13_32_1","unstructured":"WHO.Body Mass Index.2020.http:\/\/www.euro.WHO.int\/en\/health\u2010topics\/disease\u2010prevention\/nutrition\/a\u2010healthy\u2010lifestyle\/body\u2010mass\u2010index\u2010bmi"},{"key":"e_1_2_13_33_1","unstructured":"HuiqiPCT.LMSgrowth program version 2.77.2012."},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/cdn\/nzz087"},{"key":"e_1_2_13_35_1","unstructured":"NHS. National Service Scotland.Scottish Trace Element and Micronutrient Diagnostic and Research Laboratory. Vitamin D.2020.https:\/\/www.trace\u2010elements.co.uk\/vitamin\u2010d.asp"},{"key":"e_1_2_13_36_1","unstructured":"McEwanC.NHS Southampton. University Hospital NHS Trust. Validation document for 25\u2010Hydroxyvitamins D2 and D3 in plasma using LC\/MS\/MS in the Chemical Pathology Laboratory at Southampton General Hospital.2009."},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10040497"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.151.1.7812580"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.167.2.211"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2019.12.013"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569\u20101993(11)60004\u20100"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101436"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/218691"},{"key":"e_1_2_13_45_1","unstructured":"Cystic Fibrosis.Nutritional management of cystic fibrosis.2016.https:\/\/www.cysticfibrosis.org.uk\/"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.08.007"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00454.2018"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.20332"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00082\u20102019"},{"key":"e_1_2_13_50_1","unstructured":"(NIHR) NIfHR.Cystic Fibrosis Commissionary brief.2020.https:\/\/www.nihr.ac.uk\/search\u2010results.htm?search=Cystic+Fibrosis"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007298.pub4"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.04.012"}],"container-title":["Journal of Human Nutrition and Dietetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.12906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jhn.12906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.12906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T08:11:06Z","timestamp":1692778266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jhn.12906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":52,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/jhn.12906"],"URL":"https:\/\/doi.org\/10.1111\/jhn.12906","archive":["Portico"],"relation":{},"ISSN":["0952-3871","1365-277X"],"issn-type":[{"value":"0952-3871","type":"print"},{"value":"1365-277X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2020-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}