{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:51:31Z","timestamp":1772160691629,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005918","name":"Christian Medical College, Vellore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:italic>in vitro<\/jats:italic>\n                      and animal studies have shown that iron loading in pancreatic beta cells impairs insulin secretion, no human studies have documented the acute effects of oral iron on beta\u2010cell insulin secretory capacity. In the present study, we determined beta\u2010cell insulin secretory capacity at baseline and after a single oral dose of iron (ferrous sulphate, 120\u2009mg elemental iron) in healthy male individuals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifteen healthy male volunteers underwent an oral glucose tolerance test (OGTT) to document baseline glucose tolerance and insulin secretion kinetics (baseline OGTT). One week later, the same subjects underwent a second OGTT, 2\u2009h after an oral dose of ferrous sulphate (120\u2009mg of elemental iron) (post\u2010iron OGTT). Changes in disposition index, insulin secretion kinetics, glucose tolerance, insulin resistance, insulin clearance and iron\u2010related parameters in serum were determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to baseline OGTT, the areas under the curve (AUC) for serum iron and transferrin saturation increased by 125% and 118%, respectively, in the post\u2010iron OGTT. The disposition index decreased by 20% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and the AUC for glucose concentrations increased by 5.7% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) during the post\u2010iron OGTT. The insulin secretion rate was marginally lower during the first hour (\u22123.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.63), but became significantly higher during the second hour (22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005) of the post\u2010iron OGTT. Insulin resistance and insulin clearance rate were not affected by iron intake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The decrease in disposition index and glucose tolerance observed after the oral dose of iron points to an acute iron\u2010induced impairment in pancreatic beta\u2010cell insulin secretory capacity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.13074","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T03:04:33Z","timestamp":1661310273000},"page":"1111-1120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impaired pancreatic beta\u2010cell function after a single dose of oral iron: A before\u2010and\u2010after (pre\u2013post) study"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6429-3453","authenticated-orcid":false,"given":"Padmanaban","family":"Venkatesan","sequence":"first","affiliation":[{"name":"Department of Biochemistry Christian Medical College  Vellore Tamil Nadu India"},{"name":"Christian Medical College The Tamil Nadu Dr. MGR Medical University  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagadish","family":"Ramasamy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Christian Medical College  Vellore Tamil Nadu India"},{"name":"Christian Medical College The Tamil Nadu Dr. MGR Medical University  Chennai India"},{"name":"All India Institute of Medical Sciences  Madurai Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vanitha","sequence":"additional","affiliation":[{"name":"Christian Medical College The Tamil Nadu Dr. MGR Medical University  Chennai 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