{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:49:28Z","timestamp":1754110168837,"version":"3.37.3"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Branched chain amino acid (BCAA) supplementation may influence glucose metabolism in individuals with an impaired glyceamic profile. This systematic review investigated the effects of isolated BCAA supplementation on measures of glucose homeostasis in individuals with hepatic disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Web of Science, Cochrane Library and Scopus for published clinical trials that investigated the effects of isolated BCAA supplementation on measures of glucose homeostasis, including serum glucose and insulin, glycated haemoglobin (HbA1c) levels and homeostatic model assessment for insulin resistance (HOMA\u2010IR) scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven trials met the inclusion criteria. Only one study revealed a decrease in serum glucose from BCAA supplementation compared to three studies that showed increases. Five studies demonstrated no significant changes in serum glucose, and two studies displayed no changes in HbA1c following BCAA supplementation. Serum levels of insulin were decreased in three studies, remained unchanged in one, and increased in the remaining three studies. BCAA supplementation reduced HOMA\u2010IR scores in two studies, increased HOMA\u2010IR scores in another two, or resulted in no changes in two other studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>BCAA supplementation in isolation had no effect on overall glucose homeostasis in individuals with hepatic disorders, although some improvements on serum insulin levels and HOMA\u2010IR scores were observed. Overall, there is little evidence to support the utilisation of BCAA supplementation as a potential nutritional strategy for improving measures of glucose homeostasis in individuals with hepatic disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.13076","type":"journal-article","created":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T07:08:07Z","timestamp":1661238487000},"page":"603-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of branched\u2010chain amino acid supplementation on measures of glucose homeostasis in individuals with hepatic disorders: A systematic review of clinical studies"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6264-9388","authenticated-orcid":false,"given":"Konstantinos","family":"Prokopidis","sequence":"first","affiliation":[{"name":"Department of Musculoskeletal Biology, Institute of Life Course and Medical Sciences University of Liverpool Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard P.","family":"Kirwan","sequence":"additional","affiliation":[{"name":"School of Biological and Environmental Sciences Liverpool John Moores University Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1037-1983","authenticated-orcid":false,"given":"Panagiotis","family":"Giannos","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Natural Sciences Imperial College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos K.","family":"Triantafyllidis","sequence":"additional","affiliation":[{"name":"Department of Nutrition &amp; Dietetics Musgrove Park Hospital, Taunton &amp; Somerset NHS Foundation Trust Taunton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6681-8479","authenticated-orcid":false,"given":"Konstantinos S.","family":"Kechagias","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Faculty of Medicine Imperial College London UK"},{"name":"Department of Nutrition &amp; Dietetics Chelsea and Westminster Hospital NHS Foundation Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott C.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Physical Education Studies, Faculty of Education Brandon University Brandon MB Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darren G.","family":"Candow","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology and Health Studies University of Regina Regina SK Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.656604"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.207S"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0927"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.04.006"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00377.2020"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4057"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092545"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138889"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-014-1894-9"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.08.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101261"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4222-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2020.09.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1279"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.57.114"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510000991"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.587843"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665117002002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13010095"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.05.092"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz191"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i43.7620"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.37.429"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006580"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2004.10.010"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hepres.2005.01.009"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1370-x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-015-1067-y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.03.011"},{"key":"e_1_2_11_34_1","first-page":"1547","article-title":"Combination of branched\u2010chain amino acids and angiotensin\u2010converting enzyme inhibitor suppresses the cumulative recurrence of hepatocellular carcinoma: a randomized control trial","volume":"26","author":"Yoshiji H","year":"2011","journal-title":"Oncol Rep"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00701.x"},{"key":"e_1_2_11_36_1","first-page":"105","article-title":"Branched\u2010chain amino acid\u2010enriched supplementation improves insulin resistance in patients with chronic liver disease","volume":"22","author":"Kawaguchi T","year":"2008","journal-title":"Int J Mol Med"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2006.10.008"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(90)90278-Y"},{"key":"e_1_2_11_39_1","first-page":"85","article-title":"Effect of branched\u2011chain amino acid supplementation on insulin resistance and quality of life in chronic hepatitis C patients","volume":"8","author":"Oca\u00f1a\u2011Mondrag\u00f3n A","year":"2018","journal-title":"Biomed Rep"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rgmx.2017.02.005"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001301"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.031"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.10.008"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-020-00653-x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.11R05FM"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c00726"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2003"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22688"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2850"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.36.2.199"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10583"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K10E-221"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.108977"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.22.16638"}],"container-title":["Journal of Human Nutrition and Dietetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.13076","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jhn.13076","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.13076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T08:09:27Z","timestamp":1692518967000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jhn.13076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,16]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["10.1111\/jhn.13076"],"URL":"https:\/\/doi.org\/10.1111\/jhn.13076","archive":["Portico"],"relation":{},"ISSN":["0952-3871","1365-277X"],"issn-type":[{"type":"print","value":"0952-3871"},{"type":"electronic","value":"1365-277X"}],"subject":[],"published":{"date-parts":[[2022,9,16]]},"assertion":[{"value":"2022-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}