{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T02:46:42Z","timestamp":1789094802132,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adults and children who are enterally tube\u2010fed can experience adverse gastrointestinal symptoms (GIS). Observational data suggests that blended diets (BD) could mitigate such symptoms, with potential to improve quality of life and clinical outcomes. We present a novel systematic review examining the impact of BD, compared to commercial feeds, on GIS of adults and children who are tube\u2010fed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The protocol was registered with PROSPERO (CRD42021261147). Four electronic databases were searched from inception to August 2021. Search terms included \u2018tube\u2010fed\u2019, \u2018blended diet\u2019 and \u2018formula\u2019. Inclusion criteria were intervention studies comparing blended and commercial feeds using quantitative measures of GIS. Heterogeneity of outcome measures precluded meta\u2010analysis; therefore, a narrative synthesis was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Six papers (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009219), including two randomised control trials (RCT) and four single arm pre\u2013post studies, were identified. Equal numbers studied in\u2010 and out\u2010patients, adults and children. Risk of bias was notable for all studies. Equivocal and insufficient evidence prevented consensus on outcomes of vomiting, gagging, oral intake, bloating and constipation. However, one RCT and two single arm pre\u2013post studies suggest that diarrhoea symptoms may be improved on BD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Diarrhoea is prevalent in tube\u2010fed populations and associated with adverse outcomes. Improvements in diarrhoea symptoms attributed to BD may be clinically important. Our findings are congruous with the wider observational evidence base, and support recommendations of the British Dietetic Association. BD may pose a viable alternative to commercial formula, and may mitigate symptoms of diarrhoea for adults and children who are tube\u2010fed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.13090","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T08:24:23Z","timestamp":1663748663000},"page":"673-686","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A systematic review examining the impact of blended diets on the gastrointestinal symptoms of people who are enterally fed"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-773X","authenticated-orcid":false,"given":"Esme","family":"Peers","sequence":"first","affiliation":[{"name":"Centre for Public Health Research, School of Health &amp; Life Sciences Teesside University  Middlesbrough UK"},{"name":"Fuse, The Centre for Translational Research in Public Health  Newcastle UK"},{"name":"Department of Nutrition and Dietetics Queen Elizabeth Hospital  King's Lynn UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4271-4629","authenticated-orcid":false,"given":"Ruth C.","family":"Boocock","sequence":"additional","affiliation":[{"name":"Centre for Public Health Research, School of Health &amp; Life Sciences Teesside University  Middlesbrough UK"},{"name":"Fuse, The Centre for Translational Research in Public Health  Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Burn","sequence":"additional","affiliation":[{"name":"Centre for Public Health Research, School of Health &amp; Life Sciences Teesside University  Middlesbrough UK"},{"name":"Fuse, The Centre for Translational Research in Public Health  Newcastle UK"},{"name":"UniSA Online, University of South Australia  Adelaide SA Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10493"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426506021004411"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0115426506021004408"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533617701401"},{"key":"e_1_2_11_6_1","unstructured":"DurnanS.\u2018It's just food blended': exploring parents' experiences of choosing blended diet for their tube\u2010fed child. 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