{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:40:22Z","timestamp":1780422022415,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>It has been suspected that circadian rhythms may play a part in the pathogenesis of gastrointestinal diseases including gastroesophageal reflux disease (GERD). The present study aimed to examine the cross\u2010sectional association of the timing of sleep and meals with the presence of GERD in community\u2010dwelling women in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 605 women responded to a self\u2010administered questionnaire asking for information on GERD symptoms, sleep habits, sleep disturbances and the timing of meals. GERD symptoms were evaluated using the Frequency Scale for the Symptoms of GERD, and participants with a score of more than seven points were classified as having GERD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 104 (17.2%) women were found to have GERD. Later bedtime on both weekdays and weekends and later midpoint of sleep were significantly associated with the odds ratios (OR) of GERD after controlling for covariates: ORs for each 1\u2009h delay were 1.31 (95% confidence interval [CI] = 1.03\u20131.68), 1.38 (95% CI = 1.08\u20131.75) and 1.43 (95% CI = 1.06\u20131.95). Having lunch at irregular times was significantly associated with the increased OR of GERD (1.99; 95% CI = 1.02\u20133.91). Longer overnight fasting duration and longer time intervals from the midpoint of sleep to breakfast and lunch were significantly associated with decreased OR of GERD (ORs for each 1\u2009h increase were 0.73 [95% CI = 0.56\u20130.95], 0.64 [95% CI = 0.46\u20130.88] and 0.70 [95% CI = 0.51\u20130.96]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These data suggest that the timing of sleep and timing of meals relative to the sleep\/wake cycle are associated with the presence of GERD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.13207","type":"journal-article","created":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T09:19:47Z","timestamp":1689412787000},"page":"2026-2035","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations of the timing of sleep and meals with the presence of gastroesophageal reflux disease in community\u2010dwelling women in Japan"],"prefix":"10.1111","volume":"36","author":[{"given":"Chisato","family":"Nagata","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiyo","family":"Yamakawa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuma","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7944-253X","authenticated-orcid":false,"given":"Masaaki","family":"Sugino","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoka","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Preventive Medicine Gifu University Graduate School of Medicine  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Nagao","sequence":"additional","affiliation":[{"name":"Gihoku Kousei Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Gihoku Kousei Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Gihoku Kousei Hospital  Gifu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"The natural history of gastro\u2010esophageal reflux disease; 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