{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:50:08Z","timestamp":1792533008412,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Helical intensity\u2010modulated radiotherapy (H\u2010IMRT) provides excellent limitation of dose to tissues not requiring treatment, although acute toxicity still occurs. The present study aimed to determine how treatment\u2010related acute toxicities affect nutrition outcomes in patients with head and neck cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective observational study was conducted in 194 patients undergoing curative intent H\u2010IMRT with or without other treatment modalities. Weight outcomes (kg) and acute toxicity and dysphagia data were collected during treatment using Common Toxicity Criteria for Adverse Effects (CTCAE), version 4.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant weight loss (&gt; 10%) was observed in 30% of high nutritional risk patients and 7% of low nutritional risk patients. Nausea, adjusted for baseline dysphagia, in high nutritional risk patients and nausea, dysphagia and pharyngeal mucositis in low nutritional risk patients were significant factors in explaining the percentage loss in baseline weight to treatment completion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant weight loss remains an issue during treatment, despite improvements in radiotherapy technology and high\u2010level multidisciplinary care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jhn.13243","type":"journal-article","created":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T11:24:56Z","timestamp":1695381896000},"page":"182-192","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nutrition outcomes and treatment toxicities in patients with head and neck cancer receiving helical intensity\u2010modulated radiotherapy"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-0954","authenticated-orcid":false,"given":"Claire","family":"Blake","sequence":"first","affiliation":[{"name":"Metro North Hospital and Health Service Royal Brisbane &amp; Women's Hospital Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainbow","family":"Lai","sequence":"additional","affiliation":[{"name":"School of Human Movement and Nutrition Sciences The University of Queensland Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Brown","sequence":"additional","affiliation":[{"name":"Metro North Hospital and Health Service Royal Brisbane &amp; Women's Hospital Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Pelecanos","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Moroney","sequence":"additional","affiliation":[{"name":"Metro North Hospital and Health Service Royal Brisbane &amp; Women's Hospital Brisbane QLD Australia"},{"name":"School of Health &amp; Rehabilitation Sci Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Helios","sequence":"additional","affiliation":[{"name":"Metro North Hospital and Health Service Royal Brisbane &amp; Women's Hospital Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Smith","sequence":"additional","affiliation":[{"name":"QIMR Berghofer Medical Research Institute Brisbane QLD Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett G. 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