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Chronic muscle inflammation leads to imbalanced pro\u2010inflammatory and anti\u2010inflammatory cytokines, causing inadequate nutrition, weight loss and muscle weakness during a negative cycle. Owing to its potential to modulate LGI in various diseases, the Mediterranean diet (Med Diet) has been extensively studied. This scoping review explores the nutritional implications and recommendations of the Med Diet as a treatment for immune\u2010mediated diseases, focusing on the gaps in IIM nutritional interventions. A comprehensive literature search of the MEDLINE and EBSCO databases between September 2018 and December 2022 was performed. We identified that the Med Diet and its specific components, such as omega\u20103 (n\u03c93) fatty acids, vitamin D and antioxidants, play a role in the dietary treatment of connective tissue\u2010related autoimmune diseases. Nutritional interventions have demonstrated potential for modulating disease activity and warrant further exploration of IIMs through experimental studies. This review introduces a dietary therapeutic approach using the Med Diet and related compounds to regulate chronic inflammatory processes in IIMs. However, further clinical studies are required to evaluate the efficacy of the Med Diet in patients with IIMs. Emphasising a clinical\u2013nutritional approach, this study encourages future research on the anti\u2010inflammatory effects of the Med Diet on IIMs. This review highlights potential insights for managing and treating these conditions using a holistic approach.<\/jats:p>","DOI":"10.1111\/jhn.13287","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T12:09:56Z","timestamp":1707307796000},"page":"772-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nutritional interventions as modulators of the disease activity for idiopathic inflammatory myopathies: a scoping review"],"prefix":"10.1111","volume":"37","author":[{"given":"Abril I.","family":"S\u00e1nchez\u2010Rosales","sequence":"first","affiliation":[{"name":"School of Public Health, Instituto Nacional de Salud P\u00fablica, Universidad No. 655, Colonia Santa Mar\u00eda Ahuacatitl\u00e1n, Cerrada Los Pinos y Caminera, Cuernavaca Morelos Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan G.","family":"Posadas\u2010Calleja","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine University of Calgary Calgary Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora E.","family":"Serralde\u2010Z\u00fa\u00f1iga","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Service, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Ciudad de M\u00e9xico  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0144-0377","authenticated-orcid":false,"given":"Gabriela","family":"Quiroz\u2010Olgu\u00edn","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Service, Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n, Ciudad de M\u00e9xico  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"DourmishevL DourmishevA. 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