{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:11:12Z","timestamp":1788635472965,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The beneficial effects of n\u20103 polyunsaturated fatty acids (PUFA) in reducing high blood triglyceride (TG) levels have been well demonstrated. This study aimed to investigate the effect of chia seeds on blood TG and its associated cardiometabolic factors in hypertriglyceridaemic individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This three\u2010group randomised controlled trial compared the effects of a low\u2010calorie diet (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922), a low\u2010calorie diet with chia seeds (30\u2009g\/day,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) or a low\u2010calorie diet with concentrated fish oil (1.8\u2009g\/day of n\u20103 long\u2010chain PUFAs,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200922) in patients with hypertriglyceridaemia. Anthropometrics, fasting blood lipids, proprotein convertase subtilisin\/kexin type 9, insulin, adiponectin, leptin and interleukin\u20106 levels were measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 8 weeks, the mean reduction in weight exhibited by the three groups was not statistically different (2.0, 2.7 and 2.8\u2009kg, respectively, for the control, fish oil and chia seed groups). The plasma TG decreased in both the chia seed and fish oil groups in comparison to the control group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). However, no significant difference was observed between the chia seed and fish oil groups (change from baseline mean: 145.2 and 136.7\u2009mg\/dL for the chia seed and fish oil groups, respectively). The consumption of chia seeds was associated with a reduction in diastolic blood pressure (change from baseline mean: 8.4\u2009mmHg) compared to the other two groups. No significant alterations were observed in the other blood biochemical factors between the three groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In people with moderate hypertriglyceridaemia, a low\u2010calorie diet with 30\u2009g of chia seeds compared to fish oil supplements containing 1.8\u2009g of long\u2010chain PUFAs has a similar effect on reducing plasma TG levels, whereas it has a higher blood pressure\u2013lowering effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.13369","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T06:39:45Z","timestamp":1727937585000},"page":"1558-1570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of chia seeds or concentrated fish oil on cardiometabolic risk markers in subjects with hypertriglyceridaemia: a parallel clinical trial"],"prefix":"10.1111","volume":"37","author":[{"given":"Mohammad Reza","family":"Shahparvari","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9133-1870","authenticated-orcid":false,"given":"Javad","family":"Nasrollahzadeh","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran 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