{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:56:22Z","timestamp":1783655782916,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study investigated the prevalence of malnutrition at childhood cancer diagnosis in South Africa and the association with 1\u2010year post\u2010diagnosis overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Nutritional status was prospectively assessed for newly diagnosed children with cancer. Chronic undernutrition was defined as two standard deviations (SDs) or more below zero for height\/length\u2010for\u2010age (HAZ), and acute as underweight (weight\u2010for\u2010age [WAZ], and wasted as body mass index for age [BAZ] and mid\u2010upper arm circumference for age [MUAC\/A]). The association between the nutritional status at diagnosis and age, sex, disease group and 1\u2010year post\u2010diagnosis OS was analysed with Cox regression and hazard ratios (HRs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Less than 15% were chronically malnourished (stunted: 14.3%) and up to 24.3% acutely undernourished (wasted: 24.3% MUAC\u2010Z and BAZ 8.1%), 11.6% underweight, of 320 patients at cancer diagnosis). More females than males were underweight (12.2% vs. 4.5%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.027). Children of 5 years of age and older had a higher prevalence of wasting (18.7%) than children under 5 years of age (3.9%) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) at diagnosis, with significant improvement 6 months after diagnosis. Stunting was significantly associated with poorer OS at 3 years after a cancer diagnosis (HR 1.8; 95% CI 1.1, 2.8;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MUAC\/A identified more children with undernutrition than other nutritional parameters. Stunting was significantly associated with poorer OS 3 years and EFS 2 years after a cancer diagnosis. Optimal nutritional support should be provided for South African children, especially those with acute and chronic malnutrition, to improve OS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.70082","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T06:45:47Z","timestamp":1751611547000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prevalence of Chronic and Acute Malnutrition and Association With Overall Three\u2010Year Survival in Newly Diagnosed Children With Cancer in South Africa"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6154-3653","authenticated-orcid":false,"given":"Judy","family":"Schoeman","sequence":"first","affiliation":[{"name":"Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences Stellenbosch University, Tygerberg Hospital Cape Town South Africa"},{"name":"Department of 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