{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:08:56Z","timestamp":1772982536817,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The benefits of diets on patients with migraine remain elusive. We aimed to determine rates of improvement and predictors of response of migraine after an intensive dietary intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a quasi\u2010experimental pre\u2010post study including patients with self\u2010reported digestive functional disorders and migraine undertaking a social\u2010media based program with a 2\u2010week dietary intervention (low\u2010FODMAP, low\u2010starch and low\u2010 sucrose diet). Migraine improvement was defined as a decrease of at least 50% in intensity or frequency of headaches. Independent variables associated with clinical improvement were identified with multivariable logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 7677 patients with migraine and digestive disorders undertook the B15 program; 4628 (60.3%) showed improvement of migraine after the dietary intervention. The intensity (6.1 vs. 3.8) and frequency (3.4 days vs. 2.5 days) of headaches significantly reduced after the diet. Patients who improved were younger and more likely to report heartburn and dyspepsia. The presence of depressive symptoms was also more common in patients with response. The mean Migraine Disability Assessment (MIDAS) score was significantly higher in patients with good response (27.5 vs. 18.5). Age, presence of dyspepsia, higher MIDAS score, and migraine with severe disability were independent predictors of migraine improvement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A low\u2010FODMAP diet was associated with improvement of migraine in a large proportion of patients with functional digestive disorders. Further research on how dietary approaches targeting the gut\u2010brain axis can improve the quality of life of patients with digestive disorders and migraine is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.70104","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:47:24Z","timestamp":1753350444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gut\u2010Brain Axis and Migraine: Rates of Improvement and Predictors of Response After a Low\u2010FODMAP, Low\u2010Starch and Low\u2010Sucrose Dietary Intervention"],"prefix":"10.1111","volume":"38","author":[{"given":"Facundo","family":"Pereyra","sequence":"first","affiliation":[{"name":"Gastroenterology Department Cipoletti Hospital R\u00edo Negro Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-0559","authenticated-orcid":false,"given":"Francisco","family":"Schlottmann","sequence":"additional","affiliation":[{"name":"Department of Surgery Hospital Alem\u00e1n Buenos Aires Argentina"},{"name":"Department of Surgery University of Illinois at Chicago Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Carnero Contentti","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Salvatori","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Cipoletti Hospital R\u00edo Negro Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Barbagelata","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Cipoletti Hospital R\u00edo Negro Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Carlos Durand Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisandro","family":"Pereyra","sequence":"additional","affiliation":[{"name":"Gastroenterology Department Hospital Alem\u00e1n Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30322-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-018-0846-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32160-7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-023-01175-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13300"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-1078-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01303.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16193415"},{"issue":"2","key":"e_1_2_11_11_1","first-page":"87","article-title":"Association of Dietary Patterns With Migraine: A Matched Case\u2010Control Study","volume":"22","author":"Martami F.","year":"2023","journal-title":"Current Journal of Neurology"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1510809"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16590"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001372"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142222"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14845"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13061894"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1997.142318000.x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14161"},{"issue":"6","key":"e_1_2_11_20_1","first-page":"S20","article-title":"Development and Testing of the Migraine Disability Assessment (MIDAS) Questionnaire to Assess Headache\u2010Related Disability","volume":"56","author":"Stewart W. F.","year":"2001","journal-title":"Neurology"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1412-71"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870251"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871526513666131201125021"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092615"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024241233979"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13030-023-00275-4"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12468"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-022-02723-0"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.04.019"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16589"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-6-26"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-021-05078-5"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711452100444X"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/1129-2377-15-69"},{"issue":"3","key":"e_1_2_11_35_1","first-page":"217","article-title":"The Effectiveness of Diet Restriction in Elderly With Migraine","volume":"58","author":"\u00d6z\u00f6n A. \u00d6.","year":"2021","journal-title":"Noro psikiyatri arsivi"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13836"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1080\/27697061.2023.2288081"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13072469"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16812"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16203515"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14459"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107511"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14806"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2005.01076.x"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4610.2002.02054.x"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncp.10404"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/1747-0080.12543"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.2016.tb00705.x"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2023.101098"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1586\/ern.11.190"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1177\/03331024251317486"}],"container-title":["Journal of Human Nutrition and Dietetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.70104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jhn.70104","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jhn.70104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:48:18Z","timestamp":1772959698000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jhn.70104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,24]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1111\/jhn.70104"],"URL":"https:\/\/doi.org\/10.1111\/jhn.70104","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1111\/JHN.70104\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1111\/JHN.70104\/v2\/review1","asserted-by":"object"}]},"ISSN":["0952-3871","1365-277X"],"issn-type":[{"value":"0952-3871","type":"print"},{"value":"1365-277X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,24]]},"assertion":[{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70104"}}