{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:30:47Z","timestamp":1793133047130,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To systematically evaluate and conduct a meta\u2010analysis on the effects of early nutritional intervention on serum albumin (ALB), hemoglobin (HB), NIH Stroke Scale (NIHSS) scores, and complication rates in stroke patients with dysphagia, providing evidence\u2010based support for clinical rehabilitation management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search was conducted in PubMed, Wiley Library, Cochrane Library, EMBASE, and Web of Science databases from inception to April 25, 2025 (the final search date). The search strategy was designed and executed by an experienced medical librarian and one investigator. Retrieved records were imported into EndNote X20 (Clarivate Analytics) for reference management and duplicate removal. Two researchers independently performed the subsequent literature screening, data extraction, and risk of bias assessment. Meta\u2010analysis was conducted using Review Manager 5.4, and publication bias was assessed using Stata 16.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 13 multicenter RCTs were included. The meta\u2010analysis indicated that the early nutritional intervention group showed significantly higher post\u2010intervention serum albumin levels (SMD\u2009=\u20092.08, 95% CI: 1.36\u20132.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001) and hemoglobin levels (SMD\u2009=\u20091.74, 95% CI: 1.04\u20132.45,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001) compared to the control group; post\u2010intervention NIHSS scores were also significantly lower in the intervention group (MD\u2009=\u2009\u22122.68, 95% CI: \u22123.20 to \u22122.16,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001); the incidence of complications was also significantly reduced (OR\u2009=\u20090.31, 95% CI: 0.19\u20130.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Sensitivity analysis showed stable results, and no significant publication bias was detected except for NIHSS scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early nutritional intervention is associated with significant improvements in key biochemical parameters, neurological deficit, and complication rates in stroke patients with dysphagia, demonstrating positive clinical application value. Future research should focus on more high\u2010quality, large\u2010sample RCTs to further validate these findings and explore optimal intervention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.70165","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T08:43:08Z","timestamp":1763714588000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Impact of Early Nutritional Intervention on Nutritional Status, Neurological Deficit, and Complications in Stroke Patients With Dysphagia: A Meta\u2010Analysis"],"prefix":"10.1111","volume":"38","author":[{"given":"Cunlei","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Neurology, The Fourth School of Clinical Medicine Zhejiang Chinese Medical University (Hangzhou First People's Hospital) Hangzhou Zhejiang 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People's Hospital, School of Medicine, Westlake University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7172-6428","authenticated-orcid":false,"given":"Qun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Chengbei Branch, Hangzhou First People's Hospital Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jch.14099"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113892037335945241029111720"},{"issue":"30","key":"e_1_2_11_4_1","first-page":"45","article-title":"Clinical Study on Early Enteral Nutrition Support in Patients With Acute Stroke and Dysphagia","volume":"20","author":"Bao Z.","year":"2013","journal-title":"China Modern 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