{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:05:57Z","timestamp":1773335157737,"version":"3.50.1"},"reference-count":56,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To map evidence for nutrition interventions during osteosarcoma (OS) treatment for children and young people (CYP), identifying gaps to inform research for this predominantly adolescent group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Scoping review following Joanna Briggs Institute methodology and PRISMA\u2010ScR guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Sources<\/jats:title>\n                    <jats:p>MEDLINE, EMBASE, CINAHL, EMCARE and CENTRAL were searched from inception to July 2025 using a three\u2010step search strategy (pilot, full, reference screening).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility Criteria<\/jats:title>\n                    <jats:p>Studies were included if they assessed nutrition interventions in patients with OS aged &lt;\u200925 years undergoing treatment. Mixed cancer cohorts were eligible if &gt;\u200950% had OS or OS data were reported separately. Exclusions: qualitative studies, patients &gt;\u200925 years, survivors, animal or in vitro studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data Extraction and Synthesis<\/jats:title>\n                    <jats:p>Four reviewers independently screened studies. Data on methodologies, nutrition interventions, outcomes and study design limitations were extracted and reported descriptively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 7874 records retrieved, 15 studies (2001\u20132024) from 4 high\u2010 and 4 middle\u2010income countries met inclusion, involving 964 participants (median age 13.3 years), including 5 conference abstracts. Ten studies addressed comprehensive nutrition support (macro\u2010 and micronutrients), mostly using retrospective cohorts, while five focused on micronutrients. Common interventions included parenteral nutrition (5\/15) and early gastrostomy feeding (5\/15). Ten peer\u2010reviewed studies were fully characterised against the review objectives: six examined appetite stimulants, oral, enteral, and parenteral nutrition, or compared early versus reactive gastrostomy, reporting outcomes mainly via BMI\n                      <jats:italic>Z<\/jats:italic>\n                      \u2010scores; four reported gastrostomy complications. Two case reports described thiamine deficiency, and two RCTs assessed magnesium and vitamin D supplementation in relation to febrile neutropenia and survival. Key limitations included small cohorts, incomplete intervention reporting and unvalidated outcome measures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Research on nutrition interventions in CYP with OS is scarce, heterogeneous and methodologically weak. Large, prospective, multi\u2010centre studies are urgently needed to establish evidence\u2010based nutrition support strategies, valid outcome measures, and to examine the psychological impact of tube feeding for young people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.70172","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T09:40:57Z","timestamp":1764322857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutrition Support Interventions for Children and Young People Treated for Osteosarcoma: A Scoping Review"],"prefix":"10.1111","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9661-5764","authenticated-orcid":false,"given":"Laura","family":"Sealy","sequence":"first","affiliation":[{"name":"Department of Paediatric Nutrition and Dietetics Bristol Royal Hospital for Children Bristol UK"},{"name":"Children's Health and Exercise Centre, Faculty of Public Health and Sports Sciences, Medical School University of Exeter Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maddie","family":"Smith","sequence":"additional","affiliation":[{"name":"Children's Health and Exercise Centre, Faculty of Public Health and Sports Sciences, Medical School University of Exeter Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Barrett","sequence":"additional","affiliation":[{"name":"Library and Knowledge Service University Hospitals Bristol &amp; Weston NHS Foundation Trust Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Divyalakshmi","family":"Bhaskaran","sequence":"additional","affiliation":[{"name":"Leeds Institute of Medical Research, St. James' Institute of Oncology, Bradford Teaching Hospitals NHS Foundation Trust University of Leeds Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Rees","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology Bristol Royal Hospital for Children Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Revuelta","family":"Iniesta","sequence":"additional","affiliation":[{"name":"Children's Health and Exercise Centre, Faculty of Public Health and Sports Sciences, Medical School University of Exeter Exeter UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28117","article-title":"The Influence of Nutrition on Clinical Outcomes in Children With Cancer","volume":"67","author":"Barr R. 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