{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:34:11Z","timestamp":1791398051860,"version":"4.3.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Human Nutrition Diet"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>\n                      Ginger (\n                      <jats:italic>Zingiber officinale<\/jats:italic>\n                      L.) contains bioactive compounds with vasodilatory properties that may benefit blood pressure (BP) regulation. However, findings from studies remain inconsistent. This systematic review and meta\u2010analysis aimed to evaluate the effect of ginger supplementation on BP in adults.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The literature was systematically searched in PubMed, Web of Science, and Scopus from database inception through May 1, 2026, to identify eligible randomized controlled trials (RCTs) evaluating systolic and diastolic blood pressure (SBP, DBP). Pooled effect estimates were calculated as weighted mean differences (WMDs) using a random\u2010effects model. Subgroup and sensitivity analyses, publication bias assessments, and both linear and nonlinear dose\u2013response analyses were conducted. The risk of bias was evaluated using the RoB 2 tool, and the certainty of the evidence was assessed according to the GRADE framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve unique RCTs contributed 13 effect sizes for SBP and 12 effect sizes for DBP. Ginger supplementation significantly reduced SBP (WMD: \u20135.03\u2009mmHg, 95% CI: \u20138.49, \u20131.57;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004) and DBP (WMD: \u20132.03\u2009mmHg, 95% CI: \u20133.90, \u20130.15;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.034). Subgroup\u2010specific reductions were observed in trials enrolling participants with elevated baseline BP, using doses \u2265\u20092000 mg\/day, including both sexes, and enrolling participants with obesity. Nonlinear dose\u2013response analyses confirmed a significant inverse association between ginger dose and BP, whereas intervention duration had no meaningful influence. Findings remained robust in sensitivity analyses, and no evidence of publication bias was detected. GRADE assessment rated the certainty of the evidence as low, downgraded only for inconsistency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ginger supplementation was associated with modest reductions in BP, with potentially greater effects in higher\u2010risk populations and at doses \u2265\u20092000 mg\/day. However, substantial heterogeneity, short trial durations, and limited robustness of the DBP findings reduce confidence in these estimates. Further high\u2010quality, long\u2010term RCTs are needed before definitive clinical or dosing recommendations can be made.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jhn.70329","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:40:33Z","timestamp":1786120833000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ginger Supplementation and Blood Pressure in Adults: A GRADE\u2010Based Systematic Review and Dose\u2010Response Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4388-0214","authenticated-orcid":false,"given":"Mehdi","family":"Karimi","sequence":"first","affiliation":[{"name":"Faculty of Medicine Bogomolets National Medical University Kyiv 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