{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T01:31:51Z","timestamp":1724895111628},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T00:00:00Z","timestamp":1351123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>As the risk involved with systemic antimicrobials (high doses, microbial resistance, adverse reactions, etc.) restricts their use and local delivery of antimicrobials into periodontal pockets improves periodontal health, this study was designed to investigate the effects of subgingivally delivered clarithromycin (<jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content>; 0.5%) as an adjunct to nonsurgical mechanotherapy in chronic periodontitis subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010eight patients were categorized into two treatment groups: scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) plus 0.5% <jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> (test; group 1) and <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> plus placebo (control; group 2). Clinical parameters included gingival index (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>), sulcus bleeding index (<jats:styled-content style=\"fixed-case\">SBI<\/jats:styled-content>), plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), and periodontal attachment level (<jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content>), recorded at 4, 8 and 12\u00a0weeks. The concentration of 0.5% <jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> in gingival fluid was estimated by reverse\u2010phase high pressure liquid chromatography. <jats:sc>anova<\/jats:sc>, the chi\u2010square test and the <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>catterthwaite test were used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients treated with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> showed enhanced reductions in <jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> SBI<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, and gains in <jats:styled-content style=\"fixed-case\">PAL<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) over time, as compared with the placebo group. However, no statistically significant differences were noted for <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>. The mean concentration of <jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> was detected in gingival crevicular fluid for up to 7\u00a0weeks, fulfilling the conditions for a controlled\u2010release device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjunctive use of 0.5% <jats:styled-content style=\"fixed-case\">CLM<\/jats:styled-content> as a controlled drug delivery system enhanced the clinical outcome up to 3\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12009","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T08:08:36Z","timestamp":1351152516000},"page":"23-31","source":"Crossref","is-referenced-by-count":8,"title":["Evaluation of subgingivally delivered 0.5% clarithromycin as an adjunct to nonsurgical mechanotherapy in the management of chronic periodontitis: a short\u2010term double blinded randomized control trial"],"prefix":"10.1111","volume":"5","author":[{"given":"Rahul","family":"Kathariya","sequence":"first","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Pradeep","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"Raghavendra","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahul","family":"Gaikwad","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry Sharad Pawar Dental College and Hospital Wardha India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.11.655"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1987.tb01573.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1981.52.3.119"},{"key":"e_1_2_8_5_1","first-page":"30","article-title":"The limits of subgingival scaling","volume":"1","author":"Stambaugh RV","year":"1981","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1974.45.8.2.601"},{"key":"e_1_2_8_7_1","first-page":"8","article-title":"A primer for osseous surgery","volume":"6","author":"Ochsenbein C","year":"1986","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.12.1675"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260305.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1995.tb00815.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.11.925"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/19424396.2000.12223067","article-title":"Responsible use of antimicrobials in periodontics","volume":"28","author":"Jorgensen MG","year":"2000","journal-title":"J Calif Dent Assoc"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.5.507"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.1.125"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1875-595X.1998.tb00721.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/30.1.27"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1995.tb02136.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1999.0404"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000238987"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700812"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh519"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/31.suppl_E.5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1179\/joc.1997.9.1.23"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/22.6.923"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.3.277"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01975835"},{"key":"e_1_2_8_27_1","first-page":"183","article-title":"Disposition and functions of clarithromycin in human THP\u20101 monocytes during stimulated and unstimulated conditions","volume":"110","author":"Ives TJ","year":"2001","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-8579(02)00187-5"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.34.6.1056"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070589"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2011.03.021"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00822.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-3659(93)90217-S"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1985.56.11s.81"},{"key":"e_1_2_8_35_1","first-page":"111","article-title":"The role of antibiotics in the treatment of periodontitis (Part 2 \u2013 controlled drug delivery)","volume":"3","author":"Needleman IG","year":"1995","journal-title":"Eur J Prosthodont Restor Dent"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.8s.782"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080013"},{"key":"e_1_2_8_38_1","first-page":"592","article-title":"Overview of patient compliance with medication dosing: a literature review","volume":"6","author":"Greenberg RN","year":"1984","journal-title":"Clin Ther"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.11.3000"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.07.022"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01793859"},{"key":"e_1_2_8_42_1","unstructured":"PiccolominiR Di BonaventuraG CatamoG NeriM.In vitro activity of clarithromycin against intracellular Helicobacter pylori. In Program and Abstracts of the 4th International Conference on the Macrolides Azalides Streptogramins and Ketolides (ICMASK IV) Barcelona Spain.1998; abstract 7.09."},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.62.9.3672-3678.1994"},{"key":"e_1_2_8_44_1","first-page":"47","article-title":"Side effects of Helicobacter pylori eradication therapy","volume":"85","author":"Mirodzhev GK","year":"2007","journal-title":"Klin Med (Mosk)"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.2001.0884"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.2_suppl.52S"}],"container-title":["Journal of Investigative and Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjicd.12009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjicd.12009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jicd.12009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:36:07Z","timestamp":1696149367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jicd.12009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/jicd.12009"],"URL":"https:\/\/doi.org\/10.1111\/jicd.12009","archive":["Portico"],"relation":{},"ISSN":["2041-1618","2041-1626"],"issn-type":[{"value":"2041-1618","type":"print"},{"value":"2041-1626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,25]]}}}