{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:39:32Z","timestamp":1785224372995,"version":"3.55.0"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T00:00:00Z","timestamp":1413849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2015,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>This study compared lactoferrin (LF<\/jats:styled-content>) levels in the gingival crevicular fluid (GCF<\/jats:styled-content>) and saliva between HIV<\/jats:styled-content>\u2010infected and noninfected patients with chronic periodontitis.<\/jats:p><\/jats:sec>Methods<\/jats:title>For each subject, LF<\/jats:styled-content> levels were analyzed in one shallow site (SS<\/jats:styled-content>; PD<\/jats:styled-content> \u22643\u00a0mm), one deep site (DS<\/jats:styled-content>; PD<\/jats:styled-content> >5\u00a0mm) and in resting whole saliva. Two groups, 28 HIV<\/jats:styled-content>\u2010infected and 10 noninfected, were selected.<\/jats:p><\/jats:sec>Results<\/jats:title>Although the salivary LF<\/jats:styled-content> levels were higher in HIV<\/jats:styled-content>\u2010infected than in noninfected individuals, especially in AIDS<\/jats:styled-content> patients, this was not statistically significant (P\u00a0<\/jats:italic>>\u00a00.05). Subgingival LF<\/jats:styled-content> levels for SS<\/jats:styled-content> and DS<\/jats:styled-content> were lower among HIV<\/jats:styled-content>\u2010infected individuals, although AIDS<\/jats:styled-content> patients showed the lowest levels. Age, smoking, gender, T CD<\/jats:styled-content>4 lymphocytes levels and viral load did not influence subgingival LF<\/jats:styled-content> levels, neither for SS<\/jats:styled-content> nor for DP<\/jats:styled-content>. Positive fungal culture was observed in 24 HIV<\/jats:styled-content>\u2010infected patients, but only observed in one in the control group. Overall, LF<\/jats:styled-content> concentration was significantly higher in DS<\/jats:styled-content> than SS<\/jats:styled-content>, both in HIV<\/jats:styled-content>\u2010infected and noninfected individuals (P\u00a0<\/jats:italic><\u00a00.05) and salivary LF<\/jats:styled-content> levels were always higher than GCF<\/jats:styled-content> levels.<\/jats:bold><\/jats:p><\/jats:sec>Conclusion<\/jats:title>The data indicate that LF<\/jats:styled-content> levels in the GCF<\/jats:styled-content> and saliva are not different between HIV<\/jats:styled-content>\u2010infected and noninfected patients with chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12017","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T05:03:39Z","timestamp":1413867819000},"page":"16-24","source":"Crossref","is-referenced-by-count":8,"title":["Lactoferrin levels in gingival crevicular fluid and saliva of HIV<\/scp>\u2010infected patients with chronic periodontitis"],"prefix":"10.1111","volume":"6","author":[{"given":"Sonia Maria Soares","family":"Ferreira","sequence":"first","affiliation":[{"name":"Educational Foundation Jayme de Altavila Macei\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio Souza","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Institute of Microbiology Federal University of Rio de Janeiro Rio de Janeiro Brazil"},{"name":"Dental School Est\u00e1cio de S\u00e1 University Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra R.","family":"Torres","sequence":"additional","affiliation":[{"name":"Dental School Federal University of Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susie A.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Medical School Federal University of Rio de Janeiro Rio de Janeiro 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