{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T21:42:18Z","timestamp":1785361338031,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,12,17]],"date-time":"2012-12-17T00:00:00Z","timestamp":1355702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aims to evaluate the relation of erythrocyte indices and serum iron level with clinical and histopathological progression of oral squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty newly diagnosed <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> patients recruited for the study were divided according to tumor size int three groups. Erythrocyte indices (e.g., hemoglobin [<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b], red blood cell [<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>] count, packed cell volume [<jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content>]) and serum iron level (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.Fe) were evaluated with normal reference values, control subject, primary tumor size and histopathological grading. Correlation of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b to <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.Fe was also analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that 56.36, 61.81, and 83.63% of males and 76, 32, and 88% of female patients were anemic in terms of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b%, <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> count and <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> respectively, whereas the remainding indices and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.Fe were within normal range (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). Percent <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b, <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> count and <jats:styled-content style=\"fixed-case\">PCV<\/jats:styled-content> gradually decreased with increasing tumor size and histopathological grading (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). Moderate to weak correlation was observed between <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tumor\u2010induced hemolysis appeared to be responsible for anemia in <jats:styled-content style=\"fixed-case\">OSCC<\/jats:styled-content> and its severity increased with the progression of tumor. Moderate to weak correlation exists between <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>e probably owing to the dual requirement of iron for bone marrow and the tumor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12021","type":"journal-article","created":{"date-parts":[[2012,12,18]],"date-time":"2012-12-18T19:10:12Z","timestamp":1355857812000},"page":"65-71","source":"Crossref","is-referenced-by-count":10,"title":["Relation of erythrocyte indices and serum iron level with clinical and histological progression of oral squamous cell carcinoma in central India"],"prefix":"10.1111","volume":"5","author":[{"given":"Riyaz Ahmed","family":"Anees Ahmed","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu M.","family":"Ganvir","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay K.","family":"Hazarey","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1648"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.12.008"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00348-4"},{"issue":"5","key":"e_1_2_8_5_1","first-page":"634","article-title":"Iron content, bioavailability and factors affecting iron status of Indians","volume":"130","author":"Nair KM","year":"2009","journal-title":"Indian J Med Res"},{"key":"e_1_2_8_6_1","volume-title":"TNM classification of malignant tumour","author":"Sobin L","year":"2010"},{"key":"e_1_2_8_7_1","volume-title":"A textbook of medicine","author":"Das KVK","year":"2005"},{"key":"e_1_2_8_8_1","first-page":"612","article-title":"Anaemia and erythropoiesis in cancer","volume":"2","author":"Spivak JL","year":"2002","journal-title":"Adv Stud Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(01)00326-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-01-0160"},{"key":"e_1_2_8_11_1","first-page":"24","article-title":"Comparative analysis of erythrocytic indices in patients with gynecological diseases and gynecological neoplasms","volume":"1","author":"Stuklov NI","year":"2010","journal-title":"Klin Lab Diagn"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103380"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.COC.0000071464.83271.08"},{"key":"e_1_2_8_14_1","first-page":"187","article-title":"Early detection of carcinomas of the right colon: role of haemoglobin and mean corpuscular volume","volume":"78","author":"Rebecca WT","year":"1986","journal-title":"J Natl Med Assoc"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdp.2003.10.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-160X-2-33"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00205193"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.09-46"},{"key":"e_1_2_8_19_1","first-page":"1383","article-title":"Some mineral, trace element and heavy metal concentration in lung cancer","volume":"11","author":"Ufuk C","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"issue":"6","key":"e_1_2_8_20_1","first-page":"596","article-title":"Anaemia\u2010inducing substance (AIS) in advanced cancer: inhibitory effect of AIS on the function of erythrocytes and immunocompetent cells","volume":"78","author":"Ishiko O","year":"1987","journal-title":"Jpn J Cancer Res"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(90)90041-P"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00584-6"},{"issue":"4","key":"e_1_2_8_23_1","first-page":"1435","article-title":"Nitric oxide and peroxynitrite production by human erythrocytes: a causative factor of toxic anemia in breast cancer patients","volume":"15","author":"Deliconstantinos G","year":"1995","journal-title":"Anticancer Res"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1998.516"},{"issue":"18","key":"e_1_2_8_25_1","first-page":"961","article-title":"Hemorheologic changes in cancer patients","volume":"135","author":"Bernat SI","year":"1994","journal-title":"Orv Hetil"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.4.340"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.36.5.539"}],"container-title":["Journal of Investigative and Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjicd.12021","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjicd.12021","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jicd.12021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T08:36:18Z","timestamp":1696149378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jicd.12021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,17]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/jicd.12021"],"URL":"https:\/\/doi.org\/10.1111\/jicd.12021","archive":["Portico"],"relation":{},"ISSN":["2041-1618","2041-1626"],"issn-type":[{"value":"2041-1618","type":"print"},{"value":"2041-1626","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,17]]}}}