{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:59:04Z","timestamp":1791295144303,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Research Deputy of this university"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The haptoglobin\u2013hemoglobin (<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>p\u2013<jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b) complex plays a significant role in regulating immune responses and acts as a bacteriostatic agent. Haptoglobin polymorphisms result in different <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>b binding affinities. This study sought to assess whether <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>p\u00a02\u20102 could be a genetic determinant for increasing the risk of peri\u2010implantitis and chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Of the Iranian subjects referred to the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartment of <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>eriodontics, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>hahid <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>eheshti <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>ehran, 203 were entered into the study, including 117 patients and 86 periodontally healthy individuals. Polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) was performed for genotyping. Data were analyzed by <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ruskal\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>allis test using the <jats:styled-content style=\"fixed-case\">SPSS<\/jats:styled-content> statistics software package.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>p\u00a02\u20102, 2\u20101, and 1\u20101 did not differ significantly between patients and healthy subjects (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). The highest frequencies of <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>p\u00a01\u20101, 2\u20101, and 2\u20102 genotypes were seen in the control (7%), peri\u2010implantitis (51%) and periodontitis (64%) groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Haptoglobin polymorphisms may not play a role in development of peri\u2010implantitis or chronic periodontitis among Iranians but we strongly suggest researchers to evaluate this polymorphism in further studies on larger sample sizes, different populations, and other types of periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12028","type":"journal-article","created":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T13:23:46Z","timestamp":1359120226000},"page":"125-130","source":"Crossref","is-referenced-by-count":6,"title":["Haptoglobin gene polymorphisms in peri\u2010implantitis and chronic 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