{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T14:37:58Z","timestamp":1771857478963,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004508","name":"Prince of Songkla University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004508","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to investigate the temporal and spatial gene expression of bone morphogenetic proteins (<jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>)\u20102, \u20104, and \u20107, and transforming growth factor\u2010\u03b2 (<jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2), during the distraction process of the rabbit mandible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty rabbits each had an osteotomy on the left mandibular body, and distraction devices were fixed. After a delay of 3\u00a0days, distraction was started at a rate of 0.5\u00a0mm\/12\u00a0h for 10\u00a0days, followed by a 3\u2010week consolidation phase. Four rabbits were killed 5 and 10\u00a0days of distraction, and 1, 2, and 3\u00a0weeks after the completion of distraction. The clinical, histological, and radiographic appearances were evaluated and analyzed with the concomitant <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content> expression pattern at each interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the distraction was started, the fibrous interzone developed between the osteotomy fragments, where intramembranous ossification was noted. The quantitative expression of <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content>\u20102, \u20104, and \u20107, and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2, were increased immediately after active distraction before a gradual decline to normal levels after the third week of consolidation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that <jats:styled-content style=\"fixed-case\">BMP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TGF<\/jats:styled-content>\u2010\u03b2 play an important role in the induction of bone formation during distraction osteogenesis. The selective expression of each bone\u2010related cytokine could provide useful insight into accelerated bone maturation and the treatment of poorly\u2010healing fractures in clinical cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12034","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T11:44:20Z","timestamp":1413632660000},"page":"255-265","source":"Crossref","is-referenced-by-count":9,"title":["Quantitative expression of bone\u2010related cytokines induced by mechanical tension\u2013stress during distraction osteogenesis in a rabbit mandible"],"prefix":"10.1111","volume":"5","author":[{"given":"Thongchai","family":"Nuntanaranont","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry Prince of Songkla University Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srisurang","family":"Suttapreyasri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry Prince of Songkla University Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surapong","family":"Vongvatcharanon","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry Prince of Songkla University Hat Yai Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/7070.2002.34305"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200301000-00035"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200106000-00029"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-198901000-00038"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-197305000-00003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-199289010-00001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00003086-199001000-00003","article-title":"Clinical application of the tension\u2010stress effect for limb lengthening","volume":"250","author":"Ilizarov GA","year":"1990","journal-title":"Clin Orthop Relat Res"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1054\/jcms.2001.0263"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650081313"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.13.1580"},{"key":"e_1_2_7_12_1","first-page":"661","volume-title":"The principle of bone biology","author":"Rosen V","year":"1996"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.73"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-199001000-00005","article-title":"Bone regenerate formation in cortical bone during distraction lengthening. 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