{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T11:30:16Z","timestamp":1769686216522,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Oral squamous cell carcinoma (OSCC<\/jats:styled-content>) may be preceded by potentially malignant disorders such as leukoplakia and oral submucous fibrosis (OSF<\/jats:styled-content>). p63 in concert with p53 regulates cell proliferation and differentiation and may have a role in potentially malignant and malignant lesions of the oral cavity. The aim of the study was to evaluate and compare the expression of p53 and p63 proteins in OSCC<\/jats:styled-content>, leukoplakia, and OSF<\/jats:styled-content> by immunohistochemistry (IHC<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>Tissue sections of OSCC<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a020), leukoplakia (n<\/jats:italic>\u00a0=\u00a020), OSF<\/jats:styled-content> (n<\/jats:italic>\u00a0=\u00a020) and normal oral mucosa (n<\/jats:italic>\u00a0=\u00a010) were stained with p53 and p63 antibodies by IHC<\/jats:styled-content>. Mean labeling index (LI<\/jats:styled-content>) among the study groups were compared using the Kruskal\u2013Wallis test.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean LI<\/jats:styled-content> of p53 for OSCC<\/jats:styled-content>, leukoplakia, OSF<\/jats:styled-content>, and normal mucosa were 56.9\u00a0\u00b1\u00a021.3, 37.6\u00a0\u00b1\u00a012.6, 34.6\u00a0\u00b1\u00a08.7 and 15.1\u00a0\u00b1\u00a09, while mean LI<\/jats:styled-content> of p63 were 56.8\u00a0\u00b1\u00a019.6, 42.3\u00a0\u00b1\u00a010.5, 32.8\u00a0\u00b1\u00a012.1, and 26.4\u00a0\u00b1\u00a09.4. The mean LI<\/jats:styled-content> of p53 and p63 were significantly higher in OSCC<\/jats:styled-content>, leukoplakia and OSF<\/jats:styled-content> compared to normal mucosa (P<\/jats:italic>\u00a0<\u00a00.01; P<\/jats:italic>\u00a0<\u00a00.01).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The significant increase in expression of p53 and p63 proteins in OSCC<\/jats:styled-content>, leukoplakia, and OSF<\/jats:styled-content> suggests their role as surrogate markers of malignant transformation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12038","type":"journal-article","created":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T08:28:40Z","timestamp":1371544120000},"page":"214-219","source":"Crossref","is-referenced-by-count":25,"title":["Immunohistochemical detection of p53 and p63 in oral squamous cell carcinoma, oral leukoplakia, and oral submucous fibrosis"],"prefix":"10.1111","volume":"5","author":[{"given":"B.R.","family":"Varun","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology PMS Institute of Dental Science and Research Trivandrum Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ranganathan","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospitals Uthandi Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umadevi K.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospitals Uthandi Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Joshua","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospitals Uthandi Chennai 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