{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:01:50Z","timestamp":1775743310340,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T00:00:00Z","timestamp":1371168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009584","name":"Clinical Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009584","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2014,2]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aim of the present study was to evaluate the effectiveness of chlorhexidine (CHX<\/jats:styled-content>) with an antidiscoloration system (ADS<\/jats:styled-content>) on stain, plaque accumulation, and gingivitis.<\/jats:p><\/jats:sec>Methods<\/jats:title>A randomized, controlled clinical trial was conducted in 26 students. After a preparatory period, the students were randomly assigned to either group P<\/jats:styled-content> (placebo), group T<\/jats:styled-content>1 (0.12% CHX<\/jats:styled-content> without an ADS<\/jats:styled-content>), or group T<\/jats:styled-content>2 (0.12% CHX<\/jats:styled-content> with an ADS<\/jats:styled-content>). During the 3\u2010week experimental period, all mechanical oral hygiene was abolished. Rinsing with 10\u00a0mL mouthwash or placebo was performed twice daily under supervision. The parameters assessed on days 0, 7, 14, and 21 included the D<\/jats:styled-content>iscoloration I<\/jats:styled-content>ndex (DI<\/jats:styled-content>), P<\/jats:styled-content>laque I<\/jats:styled-content>ndex (PII<\/jats:styled-content>), and G<\/jats:styled-content>ingival I<\/jats:styled-content>ndex (GI<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>There were no significant mean differences in the DI<\/jats:styled-content>, PII<\/jats:styled-content>, or GI<\/jats:styled-content> between groups T<\/jats:styled-content>2 and P<\/jats:styled-content>. Significant mean differences existed in the DI<\/jats:styled-content> between groups T<\/jats:styled-content>2 and T<\/jats:styled-content>1 on days 14 and 21. Significant mean differences existed in the PI<\/jats:styled-content> between groups T<\/jats:styled-content>2 and T<\/jats:styled-content>1 on days 7, 14, and 21. Likewise, significant mean differences existed in the GI<\/jats:styled-content> between groups T<\/jats:styled-content>2 and T<\/jats:styled-content>1 on days 14 and 21.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>CHX<\/jats:styled-content> with an ADS<\/jats:styled-content> did not prevent plaque or gingivitis development. In fact, the CHX<\/jats:styled-content> mouthwash with an ADS<\/jats:styled-content> showed no superior effect over placebo on oral hygiene or the prevention of gingivitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12050","type":"journal-article","created":{"date-parts":[[2013,6,14]],"date-time":"2013-06-14T07:22:00Z","timestamp":1371194520000},"page":"15-22","source":"Crossref","is-referenced-by-count":31,"title":["Evaluation of the antigingivitis effect of a chlorhexidine mouthwash with or without an antidiscoloration system compared to placebo during experimental gingivitis"],"prefix":"10.1111","volume":"5","author":[{"given":"Wen","family":"Li","sequence":"first","affiliation":[{"name":"Prince Philip Dental Hospital, Faculty of Dentistry The University of Hong Kong Sai Ying Pun Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren E.","family":"Wang","sequence":"additional","affiliation":[{"name":"Prince Philip Dental Hospital, Faculty of Dentistry The University of Hong Kong Sai Ying Pun Hong Kong"},{"name":"School of Stomatology Peking University Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Finger","sequence":"additional","affiliation":[{"name":"Prince Philip Dental Hospital, Faculty of Dentistry The University of Hong Kong Sai Ying Pun Hong Kong"},{"name":"Private practice Interlaken Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Prince Philip Dental Hospital, Faculty of Dentistry The University of Hong Kong Sai Ying Pun Hong Kong"},{"name":"University of Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,14]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"The effect of suppression of the oral microflora upon the development of dental plaque and gingivitis. 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