{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:54:52Z","timestamp":1784040892554,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim was to assess the cytokine profile in the gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) of rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>) patients with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>). Databases were searched from 1991 to <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ugust 2013 using a combination of various keywords. Eight studies were included. The <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> concentrations of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u20101\u03b2, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20104, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010, matrix metalloproteinase (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20108, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u201013 and tumor necrosis factor\u2010alpha (<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1) were reported to be higher in patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> than in healthy controls (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>) without <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. In one study, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 levels in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> were significantly higher in <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients receiving anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy. One study reported no significant difference in <jats:styled-content style=\"fixed-case\">GCF TNF<\/jats:styled-content>\u2010\u03b1 levels among <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> regardless of anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 therapy. One study reported no difference in <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20101\u03b2 and prostaglandin E<jats:sub>2<\/jats:sub> levels among <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients and <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. Raised levels of proinflammatory cytokines are exhibited in the <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> of <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/jicd.12066","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T06:32:57Z","timestamp":1387521177000},"page":"1-8","source":"Crossref","is-referenced-by-count":35,"title":["Cytokine profile in the gingival crevicular fluid of rheumatoid arthritis patients with chronic periodontitis"],"prefix":"10.1111","volume":"5","author":[{"given":"Fawad","family":"Javed","sequence":"first","affiliation":[{"name":"Engineer Abdullah Bugshan Research Chair for Growth Factors and Bone Regeneration 3D Imaging and Biomechanical Laboratory College of Applied Medical Sciences King Saud University Riyadh Saudi 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