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Studies also reported elevated levels of various other acute\u2010phase reactants in periodontal disease. It has been reported extensively in the literature that treatment of periodontal infections can significantly lower serum levels of C\u2010reactive protein. Therefore, an understanding of the relationship between acute\u2010phase response and the progression of periodontal disease and other systemic health complications would have a profound effect on the periodontal treatment strategies. In view of this fact, the present review highlights an overview of acute\u2010phase reactants and their role in periodontal disease.<\/jats:p>","DOI":"10.1111\/jicd.12069","type":"journal-article","created":{"date-parts":[[2014,2,8]],"date-time":"2014-02-08T08:35:11Z","timestamp":1391848511000},"page":"108-117","source":"Crossref","is-referenced-by-count":10,"title":["Acute\u2010phase reactants in periodontal disease: Current concepts and future implications"],"prefix":"10.1111","volume":"6","author":[{"given":"Vilasan","family":"Archana","sequence":"first","affiliation":[{"name":"Department of Periodontics PMS College of Dental Science and Research Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjith","family":"Ambili","sequence":"additional","affiliation":[{"name":"Department of Periodontics PMS College of Dental Science and Research Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishnavilasam Jayakumary","family":"Nisha","sequence":"additional","affiliation":[{"name":"Department of Periodontics PMS College of Dental Science and Research Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abraham","family":"Seba","sequence":"additional","affiliation":[{"name":"Department of Periodontics PMS College of Dental Science and Research Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandran","family":"Preeja","sequence":"additional","affiliation":[{"name":"Department of Periodontics PMS College of Dental Science and Research Thiruvananthapuram India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00447.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1994.tb01213.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1998.3.1.161"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/002203459607502S07"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.1"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.32"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00189.x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2009.00319.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4439(96)00048-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199703)181:3<257::AID-PATH756>3.0.CO;2-U"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1995.9694530"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90137-6"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2230103.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.2005.B1045"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595520"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595538"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199708000-00003"},{"key":"e_1_2_10_19_1","first-page":"339","volume-title":"Cytokines in health and disease","author":"Wewers MD","year":"1997"},{"key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.21726\/rsbo.v8i3.1072","article-title":"Utilization of a biochemical kit for detection of C\u2010reactive protein (CRP) in the saliva of periodontal disease individuals","volume":"8","author":"Anaila Baroni A","year":"2011","journal-title":"RSBO"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/b414194f"},{"key":"e_1_2_10_22_1","first-page":"14","article-title":"Rheumatoid arthritis exhibits reduced acute phase and enhanced constitutive serum amyloid A protein in synovial fluid relative to serum. 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