{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T17:40:54Z","timestamp":1695490854813},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Diagnostic criteria that have been specified for unicystic ameloblastomas (<jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s) are not always helpful to differentiate these cystic tumors from common odontogenic cysts. The aim of this study therefore was to identify additional histopathological features (other than the features considered for the diagnosis of <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> at present) that would be helpful to differentiate <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> from odontogenic cysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred histopathologically confirmed unicystic ameloblastomas and 20 cases each of radicular, inflamed dentigerous and non\u2010inflamed dentigerous cysts were selected. Histopathological features of the <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s that are not used as diagnostic criteria at present were identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hyperplastic arcading epithelial proliferations with stellate\u2010reticulum\u2010like and vacuolated cells were always seen associated with inflammation in odontogenic cysts, while in <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> plexiform\u2010like areas were also seen without inflammation (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). In addition, a spiky rete pattern was observed in non\u2010inflamed <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> while this pattern was observed only in inflamed odontogenic cysts<jats:bold>.<\/jats:bold> Furthermore, spiky retes together with subepithelial hyalinization were usually observed in <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content>s while only subepithelial hyalinization was observed in non\u2010inflamed dentigerous cysts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combinations of histopathological features were identified to differentiate non\u2010inflamed <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> from common odontogenic cysts. However, presence of inflammatory changes in <jats:styled-content style=\"fixed-case\">UA<\/jats:styled-content> precludes the use of features identified in the present study for diagnostic purposes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12071","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T06:33:02Z","timestamp":1387521182000},"page":"220-225","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic dilemma of unicystic ameloblastoma: novel parameters to differentiate unicystic ameloblastoma from common odontogenic cysts"],"prefix":"10.1111","volume":"5","author":[{"given":"Kuda Singappulige Niluka Darshani","family":"Gunawardhana","sequence":"first","affiliation":[{"name":"Department of Oral Pathology Faculty of Dental Sciences University of Peradeniya Kandy Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Primali Rukmal","family":"Jayasooriya","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dental Sciences University of Peradeniya Kandy Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanninayake Mudiyanselage","family":"Tilakaratne","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Faculty of Dental Sciences University of Peradeniya Kandy Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"283","volume-title":"World Health Organization classification of tumours: pathology and genetics of head and neck tumours","author":"Barnes L","year":"2005"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197009)26:3<699::AID-CNCR2820260331>3.0.CO;2-K"},{"key":"e_1_2_6_4_1","first-page":"29","article-title":"A comparative histopathological study of epithelial 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