{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:58:49Z","timestamp":1761947929899},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to estimate the gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) levels of matrix metalloproteinases (<jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>)\u20103 and \u201013 in periodontally\u2010healthy controls and chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) patients, and also to investigate the effect of phase 1 periodontal therapy on <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and \u201013 levels in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010five systemically\u2010healthy patients were divided into two groups: group 1 (healthy) and group 2 (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>). The recording of clinical parameters and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> sampling was done at baseline for both groups and again at 6\u00a0weeks post\u2010therapy for group 2. The <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> level was determined by <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant increase in the mean <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and \u201013 was found between healthy and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> patients. There was a statistically\u2010significant reduction of <jats:styled-content style=\"fixed-case\">GCF MMP<\/jats:styled-content>\u20103 and \u201013 concentration after periodontal therapy in the <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> group. A positive correlation was found between clinical parameters and <jats:styled-content style=\"fixed-case\">GCF MMP<\/jats:styled-content>\u20103 and \u201013 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A lower concentration of <jats:styled-content style=\"fixed-case\">GCF MMP<\/jats:styled-content>\u20103 and \u201013 was found in healthy patients, and a higher concentration was noted for <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> patients, which was reduced after periodontal therapy. This indicates the important role played by these <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content> in periodontal destruction. Thus, <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\u20103 and \u201013 could be used as inflammatory biomarkers in diagnosing periodontal disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12072","type":"journal-article","created":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T06:33:07Z","timestamp":1387521187000},"page":"118-124","source":"Crossref","is-referenced-by-count":5,"title":["Effect of phase 1 periodontal therapy on gingival crevicular fluid levels of matrix metalloproteinases\u20103 and \u201013 in chronic periodontitis patients"],"prefix":"10.1111","volume":"6","author":[{"given":"Deepali D.","family":"Pawar","sequence":"first","affiliation":[{"name":"Department of Periodontics Bapuji Dental College and Hospital Davangere India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhoom S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Periodontics Bapuji Dental College and Hospital 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