{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:37:44Z","timestamp":1792118264046,"version":"4.4.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T00:00:00Z","timestamp":1393459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to evaluate the clinical and microbiological effect of systemic levofloxacin (<jats:styled-content style=\"fixed-case\">LFX<\/jats:styled-content>) as an adjunct to scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) in patients with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010five patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> were randomly divided into a test (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>33, <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">LFX<\/jats:styled-content> 500\u00a0mg, once daily [o.d.]) and a control group (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>32, <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and placebo, o.d.). Plaque index (<jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>), gingival index (<jats:styled-content style=\"fixed-case\">GI<\/jats:styled-content>), percentage of sites with bleeding on probing (%BoP), probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>) were recorded at baseline, 10\u00a0days, and 1\u2010, 3\u2010, and 6\u2010month intervals. The percentage of sites positive for <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ggregatibacter actinomycetemcomitans<\/jats:italic> (<jats:italic>A.\u00a0actinomycetemcomitans<\/jats:italic>), <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>orphyromonas gingivalis<\/jats:italic>, and <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>annerella forsythia<\/jats:italic> were recorded at baseline and at 3 and 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients receiving <jats:styled-content style=\"fixed-case\">LFX<\/jats:styled-content> showed statistically\u2010significant improvements in mean <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>. The intergroup difference in <jats:styled-content style=\"fixed-case\">PI<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> GI<\/jats:styled-content>, and%BoP was not significant at any interval. There was a reduction in the percentage of sites positive for periodontopathic bacteria over the duration of the study in both groups, and a statistically\u2010significant reduction in the number of sites positive for <jats:italic><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>.\u00a0actinomycetemcomitans<\/jats:italic> in the <jats:styled-content style=\"fixed-case\">LFX<\/jats:styled-content> group (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Levofloxacin was found to significantly improve the clinical and microbiological parameters in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> individuals.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12091","type":"journal-article","created":{"date-parts":[[2014,2,27]],"date-time":"2014-02-27T07:20:50Z","timestamp":1393485650000},"page":"170-178","source":"Crossref","is-referenced-by-count":17,"title":["Clinical and microbiological effects of levofloxacin in the treatment of chronic periodontitis: a randomized, placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"6","author":[{"given":"Avani R.","family":"Pradeep","sequence":"first","affiliation":[{"name":"Department of Periodontics Government Dental College and Research Institute Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonender P.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College and Research Institute Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh 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