{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:50:03Z","timestamp":1788871803170,"version":"build-2803163510"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["4978"],"award-info":[{"award-number":["4978"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      In the present\n                      <jats:italic>in vitro<\/jats:italic>\n                      study, we investigated the time\u2010related antimicrobial efficacy of\n                      <jats:italic>Aloe vera<\/jats:italic>\n                      and\n                      <jats:italic>Zataria multiflora<\/jats:italic>\n                      (\n                      <jats:italic>Z.\u00a0multiflora<\/jats:italic>\n                      ) plant essential oils compared to calcium hydroxide ([Ca[\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      ]\n                      <jats:sub>2<\/jats:sub>\n                      ) to eliminate\n                      <jats:italic>Enterococcus faecalis<\/jats:italic>\n                      (\n                      <jats:italic>E.\u00a0faecalis<\/jats:italic>\n                      ) from root canals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A new strain of\n                      <jats:italic>E.\u00a0faecalis<\/jats:italic>\n                      (\n                      <jats:italic>Enterococcus<\/jats:italic>\n                      spp. AGH04) was isolated from a previously root\u2010filled tooth with persistent apical periodontitis. The 16S\n                      <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content>\n                      sequence was analyzed and deposited in GeneBank under accession number\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"DDBJ\/EMBL\/GenBank\" xlink:href=\"KF465681\">KF465681<\/jats:ext-link>\n                      . A total of 108 extracted human single\u2010rooted teeth were contaminated with this bacterial strain and treated with\n                      <jats:italic>Aloe vera<\/jats:italic>\n                      essential oil,\n                      <jats:italic>Z.\u00a0multiflora<\/jats:italic>\n                      essential oil, and Ca(OH)\n                      <jats:sub>2<\/jats:sub>\n                      for 1, 7, and 14\u00a0days. Gas chromatography\u2013mass spectrometry (GC\u2013MS) was used to determine the chemical composition of the oils. The percentage reduction from initial c.f.u.\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      counts were calculated and analyzed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Carvacrol, thymol, and linalool were the main constituents of both essential oils. The c.f.u.\/\n                      <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content>\n                      count reductions significantly increased for all three medicaments when the contact time was extended. A statistically\u2010significant difference was observed between the medicaments after 1 and 7\u00a0days, but there was no significant difference after 14\u00a0days.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Both medicinal herbs showed equal antimicrobial efficiency against\n                      <jats:italic>E.\u00a0faecalis<\/jats:italic>\n                      , comparable to Ca(\n                      <jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\n                      )\n                      <jats:sub>2<\/jats:sub>\n                      for the prolonged contact time of 14\u00a0days.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jicd.12123","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T15:37:37Z","timestamp":1409845057000},"page":"93-101","source":"Crossref","is-referenced-by-count":37,"title":["Time\u2010dependent antibacterial effects of\n                    <i>Aloe vera<\/i>\n                    and\n                    <i>Zataria multiflora<\/i>\n                    plant essential oils compared to calcium hydroxide in teeth infected with\n                    <i>Enterococcus faecalis<\/i>"],"prefix":"10.1111","volume":"7","author":[{"given":"Abbas","family":"Abbaszadegan","sequence":"first","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safoora","family":"Sahebi","sequence":"additional","affiliation":[{"name":"Department of Endodontics Faculty of Dentistry Shiraz University of Medical Sciences Shiraz 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