{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:47:27Z","timestamp":1791859647783,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T00:00:00Z","timestamp":1415664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A highly\u2010regulated form of programmed cell death is apoptosis, and its perturbation has been associated with periodontal disease. Caspase\u20103 is one of the key executioners of apoptosis. The present study was designed to evaluate and correlate the levels of caspase\u20103 in gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) and serum in participants with clinically\u2010healthy periodontium, gingivitis, and chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010four sex\u2010 and age\u2010matched participants were enrolled into three groups based on clinical parameters. Group 1 participants had clinically\u2010healthy periodontium, group 2 participants had gingivitis, and group 3 participants had <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and serum samples were collected to evaluate the levels of caspase\u20103.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean caspase\u20103 concentration in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and serum was highest in group 3, followed by group 2, and was significantly correlated with gingival index, probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), and clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and the serum concentration of caspase\u20103 proportionally increases with the progression of periodontal disease, that is, gingival inflammation, <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12134","type":"journal-article","created":{"date-parts":[[2014,11,11]],"date-time":"2014-11-11T10:35:09Z","timestamp":1415702109000},"page":"174-179","source":"Crossref","is-referenced-by-count":35,"title":["Expression of key executioner of apoptosis caspase\u20103 in periodontal health and disease"],"prefix":"10.1111","volume":"7","author":[{"given":"Avani R.","family":"Pradeep","sequence":"first","affiliation":[{"name":"Department of Periodontics Government Dental College and Research Institute Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak Kumar","family":"Suke","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College and Research Institute Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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