{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T03:14:17Z","timestamp":1789528457872,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T00:00:00Z","timestamp":1434326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute of Science and Technology"},{"name":"Francisco Jos\u00e9 de Caldas-COLCIENCIAS","award":["1308-459-21661"],"award-info":[{"award-number":["1308-459-21661"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between the presence of <jats:italic>Porphyromonas\u00a0gingivalis<\/jats:italic>\u2010induced immunoglobulin G antibodies and the high\u2010density lipoprotein (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>) level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 108 individuals were examined. The presence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> was detected using primers designed to target the 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene sequence. Peripheral blood was collected from each subject to determine the levels of <jats:italic>P.\u00a0gingivalis<\/jats:italic>\u2010induced IgG1 and IgG2 serum antibodies. The <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> levels were determined using fully enzymatic methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A higher proportion of periodontitis patients had high levels of <jats:italic>P.\u00a0gingivalis<\/jats:italic>\u2010induced IgG1 and IgG2, and the proportion of subjects with a <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> level of &lt;\u00a035\u00a0md\/dL was higher in the group of chronic periodontitis patients. In the unadjusted regression model, the presence of high levels of <jats:italic>P.\u00a0gingivalis<\/jats:italic>\u2010induced IgG2 was associated with a <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> level of &lt;\u00a035\u00a0md\/dL. The adjusted model indicated that periodontitis patients with high levels of <jats:italic>P.\u00a0gingivalis<\/jats:italic>\u2010induced IgG2 showed 3.2 more chances of having pathological <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> levels (odds ratio\u00a0=\u00a03.2, 95% confidence interval\u00a0=\u00a01.2\u20139.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High levels of <jats:italic>P.\u00a0gingivalis<\/jats:italic>\u2010induced IgG2 were associated with low <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content> concentrations in patients with periodontitis, which suggests that the response of the host to periodontal infection may play an important role in the pathogenesis of cardiovascular diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12169","type":"journal-article","created":{"date-parts":[[2015,6,15]],"date-time":"2015-06-15T05:21:36Z","timestamp":1434345696000},"page":"368-375","source":"Crossref","is-referenced-by-count":3,"title":["High levels of <i>Porphyromonas gingivalis<\/i>\u2010induced immunoglobulin G2 are associated with lower high\u2010density lipoprotein levels in chronic periodontitis"],"prefix":"10.1111","volume":"7","author":[{"given":"Carlos M.","family":"Ardila","sequence":"first","affiliation":[{"name":"Biomedical Stomatology Research Group Universidad de Antioquia U de A Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Biomedical Stomatology Research Group Universidad de Antioquia U de A Medell\u00edn 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