{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T18:41:42Z","timestamp":1788633702303,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institute of Science and Technology, Francisco Jos\u00e9 de Caldas-COLCIENCIAS","award":["1308-459-21661"],"award-info":[{"award-number":["1308-459-21661"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to evaluate the association between the occurrence of periodontopathogens with cortisol levels in chronic periodontitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010five chronic periodontitis patients were invited to participate in the present study. Cortisol levels in serum were measured using an immunoassay method. <jats:italic>Porphyromonas gingivalis<\/jats:italic> (<jats:italic>P.\u00a0gingivalis<\/jats:italic>) <jats:italic>Tannerella forsythia<\/jats:italic>,<jats:italic> Treponema denticola<\/jats:italic>, and <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic> were detected by polymerase chain reaction using primers designed to target the respective 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene sequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Severe chronic periodontitis patients showed higher mean levels of cortisol (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Twenty\u2010six patients had hypercortisolemia. High cortisol levels showed a positive significant correlation with <jats:italic>P.\u00a0gingivalis<\/jats:italic> (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.237, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Of the 26 patients with hypercortisolemia, 81% had <jats:italic>P.\u00a0gingivalis<\/jats:italic>, of which 86% had severe chronic periodontitis (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). There were higher levels of cortisol with the presence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> (478.65\u00a0\u00b1\u00a0122.57 <jats:italic>vs<\/jats:italic> 402.58\u00a0\u00b1\u00a0139.60, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). The adjusted logistic regression model showed a significant association between high cortisol levels and <jats:italic>P.\u00a0gingivalis<\/jats:italic> (odds ratio\u00a0=\u00a01.7, 95% confidence interval\u00a0=\u00a01.6\u20131.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This research offers support for the association between <jats:italic>P.\u00a0gingivalis<\/jats:italic> and higher levels of cortisol in chronic periodontitis patients. These results suggest that high levels of cortisol could increase the occurrence of <jats:italic>P.\u00a0gingivalis<\/jats:italic> in the biofilm.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12175","type":"journal-article","created":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T08:37:51Z","timestamp":1437467871000},"page":"361-367","source":"Crossref","is-referenced-by-count":20,"title":["Association of <i><scp>P<\/scp>orphyromonas gingivalis<\/i> with high levels of stress\u2010induced hormone cortisol in chronic periodontitis patients"],"prefix":"10.1111","volume":"7","author":[{"given":"Carlos M.","family":"Ardila","sequence":"first","affiliation":[{"name":"Biomedical Stomatology Research Group University of Antioquia Medell\u00edn Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel C.","family":"Guzm\u00e1n","sequence":"additional","affiliation":[{"name":"Biomedical Stomatology Research Group University of Antioquia Medell\u00edn 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