{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:34:52Z","timestamp":1790361292923,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T00:00:00Z","timestamp":1448841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007271","name":"University of Tennessee Health Science Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007271","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>The aim of the present study was to test the neutralizing effect of mouthwashes on salivary pH<\/jats:styled-content> after an acidic challenge.<\/jats:p><\/jats:sec>Methods<\/jats:title>Twelve participants were recruited for three visits, one morning per week. Resting saliva was collected at baseline and after 2\u2010min swishing with 20 mL orange juice as an acidic challenge. Participants then rinsed their mouth for 30 s with 20 mL water (control), an over\u2010the\u2010counter mouthwash (Listerine), or a two\u2010step mouthwash, randomly assigned for each visit. Saliva was collected immediately, 15, and 45 min after rinsing. The pH<\/jats:styled-content> values of the collected saliva were measured and analyzed with anova<\/jats:sc>, followed by Student\u2013Newman\u2013Keuls post\u2010hoc test (significance level: 0.05).<\/jats:p><\/jats:sec>Results<\/jats:title>Orange juice significantly lowered salivary pH<\/jats:styled-content>. Immediately after rinsing, Listerine and water brought pH<\/jats:styled-content> back to baseline values, with the pH<\/jats:styled-content> significantly higher in the Listerine group. The two\u2010step mouthwash raised pH<\/jats:styled-content> significantly higher than Listerine and water, and higher than the baseline value. Salivary pH<\/jats:styled-content> returned to baseline and was not significantly different among groups at 15 and 45 min post\u2010rinsing.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Mouth rinsing after an acidic challenge increased salivary pH<\/jats:styled-content>. The tested mouthwashes raised pH<\/jats:styled-content> higher than water. Mouthwashes with a neutralizing effect can potentially reduce tooth erosion from acid exposure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12198","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T10:53:58Z","timestamp":1448880838000},"source":"Crossref","is-referenced-by-count":7,"title":["Neutralizing salivary pH<\/scp> by mouthwashes after an acidic challenge"],"prefix":"10.1111","volume":"8","author":[{"given":"Mojdeh","family":"Dehghan","sequence":"first","affiliation":[{"name":"Department of Restorative Dentistry College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daranee","family":"Tantbirojn","sequence":"additional","affiliation":[{"name":"Department of Restorative Dentistry College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Kymer\u2010Davis","sequence":"additional","affiliation":[{"name":"Summer Research Program College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colette W.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Bioscience Research College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui H","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bioscience Research College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antheunis","family":"Versluis","sequence":"additional","affiliation":[{"name":"Department of Bioscience Research College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin","family":"Garcia\u2010Godoy","sequence":"additional","affiliation":[{"name":"Department of Bioscience Research College of Dentistry University of Tennessee Health Science Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835ae8f7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2004.01282.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.36.2.3785414p682843wj"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03694.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-3382(02)70078-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e328365a24f"},{"key":"e_1_2_6_8_1","unstructured":"National Eating Disorders.org[homepage on the Internet].Get the facts on eating disorders. [cited 19 Jun 2015]. Available from:https:\/\/www.nationaleatingdisorders.org\/get-facts-eating-disorders"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047459"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/eos.12144"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2005.0317"},{"key":"e_1_2_6_12_1","unstructured":"DehghanM Versluis\u2010TantbirojnD inventors; University Of Tennessee Research Foundation assignee.Methods and compositions for preventing and treating tooth erosion. World Intellectual Property Organization patent WO2014134463 A1.2014."},{"key":"e_1_2_6_13_1","first-page":"72","article-title":"Investigative prevention for tooth erosion. 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