{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:00:59Z","timestamp":1792173659473,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T00:00:00Z","timestamp":1450310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Periodontal tissues facilitate the homing of herpes viruses that elicit the immune\u2010inflammatory response releasing the interferons (IFN<\/jats:styled-content>). IFN<\/jats:styled-content> lambda\u20101 (\u03bb<\/jats:italic>1) can suppress the replication of viruses, and induces the antiviral mechanism. The aim of the present study was to evaluate the association between IFN<\/jats:styled-content>\u2010\u03bb<\/jats:italic>1 and periodontal herpes viruses in the immunoregulation of chronic periodontal disease.<\/jats:p><\/jats:sec>Methods<\/jats:title>The cross\u2010sectional study design included 30 chronic periodontitis patients with a mean age of 42.30\u00a0\u00b1\u00a08.63\u00a0years. Gingival crevicular fluid collected was assessed for IFN<\/jats:styled-content>\u2010\u03bb<\/jats:italic>1 using enzyme\u2013linked immunosorbent assay and four herpes viruses were detected using multiplex polymerase chain reaction technique. IFN<\/jats:styled-content>\u2010\u03bb<\/jats:italic>1 levels were compared between virus\u2010positive and \u2010negative patients for individual and total viruses.<\/jats:p><\/jats:sec>Results<\/jats:title>Fifty per cent (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>15) of patients were positive for the four herpes viruses together; 50% (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>15), 30% (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>9), 26.7% (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>8), and 40% (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>12) were positive for herpes simplex virus (HSV<\/jats:styled-content>)\u20101, Epstein\u2013Barr virus, HSV<\/jats:styled-content>\u20102, and human cytomegalovirus, respectively. The mean concentrations of IFN<\/jats:styled-content>\u2010\u03bb<\/jats:italic>1 in virus\u2010positive patients (14.38\u00a0\u00b1\u00a013.95) were lower than those of virus\u2010negative patients (228.26\u00a0\u00b1\u00a0215.35). INF<\/jats:styled-content>\u2010\u03bb<\/jats:italic>1 levels in individual virus groups were also lower in virus\u2010positive patients compared to virus\u2010negative patients, with P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>These results suggest that IFN<\/jats:styled-content>\u2010\u03bb<\/jats:italic>1 could have antiviral and therapeutic value against the viruses in the pathogenesis of chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12200","type":"journal-article","created":{"date-parts":[[2015,12,17]],"date-time":"2015-12-17T15:00:49Z","timestamp":1450364449000},"source":"Crossref","is-referenced-by-count":20,"title":["Association of interferon lambda\u20101 with herpes simplex viruses\u20101 and \u20102, Epstein\u2013Barr virus, and human cytomegalovirus in chronic periodontitis"],"prefix":"10.1111","volume":"8","author":[{"family":"Muzammil","sequence":"first","affiliation":[{"name":"Division of Periodontics Department of Preventive Dental Sciences Buraydah College of Pharmacy and Dentistry Buraydah Private Colleges Buraydah Al\u2010Qassim Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Jayanthi","sequence":"additional","affiliation":[{"name":"Department of Periodontics M.R. Ambedkar Dental College and Hospital Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Faizuddin","sequence":"additional","affiliation":[{"name":"Department of Periodontics M.R. 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