{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T20:23:17Z","timestamp":1780690997995,"version":"3.54.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,14]],"date-time":"2016-03-14T00:00:00Z","timestamp":1457913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Statins are known to have a beneficial effect in the treatment of chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>). The current study was designed to investigate the effectiveness of a 1.2% atorvastatin (<jats:styled-content style=\"fixed-case\">ATV<\/jats:styled-content>) local drug delivery system as an adjunct to scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) in the treatment of intrabony defects (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> among smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010one smokers with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> were categorized into two treatment groups: <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> + 1.2% <jats:styled-content style=\"fixed-case\">ATV<\/jats:styled-content> gel and <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> + placebo gel. Clinical parameters, modified sulcus bleeding index, probing depth, and clinical attachment level were recorded at baseline before <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and at 3, 6, and 9 months. At baseline, 6 months, and 9 months, the percentage of radiographic defect depth reduction was determined using computer\u2010aided software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean probing depth reduction and mean clinical attachment level gain were found to be greater in the <jats:styled-content style=\"fixed-case\">ATV<\/jats:styled-content> group than the placebo group at 3, 6, and 9 months. A significantly greater mean percentage of radiographic defect depth reduction was found in the <jats:styled-content style=\"fixed-case\">ATV<\/jats:styled-content> group compared to the placebo group after 9 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">ATV<\/jats:styled-content> local drug delivery as an adjunct to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> can be used in the treatment of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> among smokers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12213","type":"journal-article","created":{"date-parts":[[2016,3,18]],"date-time":"2016-03-18T11:46:54Z","timestamp":1458301614000},"source":"Crossref","is-referenced-by-count":27,"title":["Subgingivally delivered 1.2% atorvastatin in the treatment of chronic periodontitis among smokers: a randomized, controlled clinical trial"],"prefix":"10.1111","volume":"8","author":[{"given":"Minal","family":"Kumari","sequence":"first","affiliation":[{"name":"Department of Periodontics Vydehi Institute of Dental Sciences and Research Centre Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh S.","family":"Martande","sequence":"additional","affiliation":[{"name":"Department of Periodontics Dr D.Y. 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