{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:32:22Z","timestamp":1790382742991,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T00:00:00Z","timestamp":1461024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Alendronate (ALN<\/jats:styled-content>) and atorvastatin (ATV<\/jats:styled-content>) are known to inhibit osteoclastic bone resorption and were proposed to have osteostimulative properties. The aim of the study was to evaluate and compare the efficacy of 1% ALN<\/jats:styled-content> and 1.2% ATV<\/jats:styled-content> gel as a local drug\u2010delivery system in adjunct to scaling and root planning (SRP<\/jats:styled-content>) for the treatment of intrabony defects in chronic periodontitis patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 90 intrabony defects were treated with either 1% ALN<\/jats:styled-content>, 1.2% ATV<\/jats:styled-content>, or placebo gel. Clinical parameters (plaque index, modified sulcus bleeding index, probing depth (PD<\/jats:styled-content>), and clinical attachment level (CAL<\/jats:styled-content>)) were recorded at baseline, 3, 6, and 9 months. Intrabony defect depth (IBD<\/jats:styled-content>) and defect depth reduction (DDR<\/jats:styled-content>%) was calculated on standardized radiographs at 6 and 9 months.<\/jats:p><\/jats:sec>Results<\/jats:title>The mean PD<\/jats:styled-content> reduction, CAL<\/jats:styled-content> gain, and DDR<\/jats:styled-content>% were greater in the ALN<\/jats:styled-content> and ATV<\/jats:styled-content> group than in the placebo group at 3, 6, and 9 months. Furthermore, a significantly greater DDR<\/jats:styled-content>% was found in the ALN<\/jats:styled-content> group at 6 and 9 months than in the ATV<\/jats:styled-content> and placebo groups.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Local delivery of 1% ALN<\/jats:styled-content> results in significantly greater improvement in PD<\/jats:styled-content>, CAL<\/jats:styled-content>, IBD<\/jats:styled-content> depth, and DDR<\/jats:styled-content>% as compared to 1.2% ATV<\/jats:styled-content> gel.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12215","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T05:18:23Z","timestamp":1461043103000},"source":"Crossref","is-referenced-by-count":31,"title":["Comparative evaluation of subgingivally delivered 1% alendronate versus 1.2% atorvastatin gel in treatment of chronic periodontitis: a randomized placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"8","author":[{"given":"Avani 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