{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:15:58Z","timestamp":1761920158036,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A bidirectional relationship exists between diabetes and periodontitis. In the present clinical trial, we evaluated the effects of non\u2010surgical periodontal therapy (<jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content>) on insulin resistance in patients with type <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) and chronic periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty chronic periodontitis patients with type <jats:styled-content style=\"fixed-case\">II DM<\/jats:styled-content> were selected and equally allocated to case and control groups. All patients were assessed for periodontal parameters and systemic parameters. The case group received <jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content>, and both groups were re\u2010evaluated after 3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All periodontal parameters were found to be significantly improved in the case group compared to the control group 3 months after <jats:styled-content style=\"fixed-case\">NSPT<\/jats:styled-content>. The mean differences in systemic parameters, such as fasting serum C\u2010peptide, Homeostasis Assessment (<jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>) Index\u2013insulin resistance, and <jats:styled-content style=\"fixed-case\">HOMA<\/jats:styled-content>\u2013insulin sensitivity, from baseline to 3 months for the case group were 0.544 \u00b1 0.73, 0.54 \u00b1 0.63, and \u201325.44 \u00b1 36.81, respectively; for the control group, they were significant at \u20131.66 \u00b1 1.89, \u20131.48 \u00b1 1.86, and 31.42 \u00b1 38.82 respectively (<jats:italic>P<\/jats:italic> &lt; 0.05). There was a significant decrease in fasting blood glucose and glycosylated hemoglobin A1c from baseline to 3 months in the case group (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study showed that periodontal inflammation could affect glycemic control and insulin resistance. Effective periodontal therapy reduced insulin resistance and improved periodontal health status and insulin sensitivity in patients with type <jats:styled-content style=\"fixed-case\">II DM<\/jats:styled-content> and chronic periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12221","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T10:25:18Z","timestamp":1465554318000},"source":"Crossref","is-referenced-by-count":24,"title":["Effect of non\u2010surgical periodontal therapy on insulin resistance in patients with type <scp>II<\/scp> diabetes mellitus and chronic periodontitis, as assessed by C\u2010peptide and the Homeostasis Assessment Index"],"prefix":"10.1111","volume":"8","author":[{"given":"Jerry","family":"Mammen","sequence":"first","affiliation":[{"name":"Department of Periodontics Government Dental College Calicut Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosamma Joseph","family":"Vadakkekuttical","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College Calicut Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseraj Manaloor","family":"George","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College Calicut Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaishid Ahadal","family":"Kaziyarakath","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College Calicut Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandni","family":"Radhakrishnan","sequence":"additional","affiliation":[{"name":"Department of Periodontics Government Dental College Calicut Kerala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12284"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2008.0363"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2284-1"},{"issue":"1","key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.2337\/dc10-S062","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","author":"American Diabetes A","year":"2010","journal-title":"Diabetes Care"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.11.002"},{"key":"e_1_2_5_7_1","first-page":"107","article-title":"Periodontal disease and diabetes mellitus. 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