{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:49:23Z","timestamp":1788648563743,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T00:00:00Z","timestamp":1467936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Host\u2010related factors could be important to the fundamental understanding of oral diseases. One such factor is matrix metalloproteinases (MMP<\/jats:styled-content>). MMP<\/jats:styled-content>3<\/jats:italic> (stromelysin 1) is crucial in connective tissue remodeling. Promoter regions are specific segments of DNA<\/jats:styled-content> that control the rate of mRNA<\/jats:styled-content> synthesis. Thus, polymorphism in the (5A\/6A) promoter region of the MMP<\/jats:styled-content>3<\/jats:italic> gene results in different transcriptional activities and is related to susceptibility in diseases. The aim of the present study was to detect polymorphism in the MMP<\/jats:styled-content>3<\/jats:italic> gene\u2010promoter region in oral submucous fibrosis patients (OSF<\/jats:styled-content>), oral squamous cell carcinoma patients (OSCC<\/jats:styled-content>), and normal individuals with tobacco and areca nut habit and without lesions, and to correlate the genotype as a risk factor in these diseases.<\/jats:p><\/jats:sec>Method<\/jats:title>Genomic DNA<\/jats:styled-content> from blood of OSF<\/jats:styled-content> (n<\/jats:italic> = 5), OSCC<\/jats:styled-content> (n<\/jats:italic> = 5), and normal individuals with tobacco and areca nut habit (n<\/jats:italic> = 5) and without (n<\/jats:italic> = 5) were subjected to polymerase chain reaction of the MMP<\/jats:styled-content>3<\/jats:italic> gene\u2010promoter region and DNA<\/jats:styled-content> sequencing.<\/jats:p><\/jats:sec>Results<\/jats:title>The 5A allele in the MMP<\/jats:styled-content>3<\/jats:italic> gene\u2010promoter region was observed more frequently in the OSF<\/jats:styled-content> group than the control groups. No significant difference was noted between OSCC<\/jats:styled-content> and the control groups on the 5A allele.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The results indicated that the 5A allele of the MMP<\/jats:styled-content>3<\/jats:italic> gene\u2010promoter region could be associated with OSF<\/jats:styled-content> risk factor, but not OSCC<\/jats:styled-content>, in an Indian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12228","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T08:13:34Z","timestamp":1467965614000},"source":"Crossref","is-referenced-by-count":11,"title":["Matrix metalloproteinases\u20103 gene\u2010promoter polymorphism as a risk factor in oral submucous fibrosis in an Indian population: a pilot study"],"prefix":"10.1111","volume":"8","author":[{"given":"Prajakta R.","family":"Zade","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suchitra R.","family":"Gosavi","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay K.","family":"Hazarey","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sindhu M.","family":"Ganvir","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Government Dental College and Hospital Nagpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,8]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"YlipalosaariM.Matrix Metallopriteinases (MMPs) in Oral Carcinomas. 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