{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:44:43Z","timestamp":1762641883805,"version":"3.41.2"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T00:00:00Z","timestamp":1469059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this pilot study was to determine the association between single nucleotide polymorphisms (\u2013174 G&gt;C) in the interleukin\u20106 (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic>) gene with chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) and type 2 diabetes mellitus (T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>) in south Indian population<jats:bold>.<\/jats:bold><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Genomic <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was obtained from the white blood cells of 30 patients with T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>, 30 patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, 30 patients with T2<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>, and 30 controls. <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was amplified using polymerase chain reaction with specific primers flanking the locus \u2013174 of the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106<\/jats:italic> gene and further genotyped using the restriction fragment length polymorphism method. The genotype distribution and allele frequencies between the study groups were determined using <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010test. The relative risk was estimated with a 95% confidence interval.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> group (26.7%) displayed a greater percentage of <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> genotype (<jats:italic>P<\/jats:italic> = 0.026) when compared to the control group (3.3%). A statistically\u2010significant difference in the allele frequencies was found between the control and <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> group with the C\u2010allele frequency being greater (0.13) in the <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> group than normal controls (0.02).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content> genotype was found to be the risk genotype and the C allele was found to be the risk allele for the development of <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12230","type":"journal-article","created":{"date-parts":[[2016,7,21]],"date-time":"2016-07-21T11:02:46Z","timestamp":1469098966000},"source":"Crossref","is-referenced-by-count":10,"title":["Association among interleukin\u20106 gene polymorphisms, type 2 diabetes mellitus, and chronic periodontitis: a pilot study"],"prefix":"10.1111","volume":"8","author":[{"given":"Loganathan","family":"Kavitha","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology Ragas Dental College and Hospital Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayaseelan","family":"Vijayshree Priyadharshini","sequence":"additional","affiliation":[{"name":"Central Research Laboratory Meenakshi Ammal Dental College and Hospital Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balasundaram","family":"Sivapathasundharam","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology Meenakshi Ammal Dental College and Hospital Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,21]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_6_2_1","DOI":"10.1093\/hmg\/ddr599"},{"key":"e_1_2_6_3_1","first-page":"489","article-title":"Periodontal disease \u2013 the overlooked diabetes complication","volume":"36","author":"Dunning T","year":"2009","journal-title":"Nephrol Nurs J"},{"doi-asserted-by":"publisher","key":"e_1_2_6_4_1","DOI":"10.1111\/j.1601-0825.2009.01584.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_5_1","DOI":"10.1055\/s-2005-858396"},{"doi-asserted-by":"publisher","key":"e_1_2_6_6_1","DOI":"10.2334\/josnusd.52.431"},{"volume-title":"Carranza's Clinical Periodontology","year":"2003","author":"Newman MG","key":"e_1_2_6_7_1"},{"volume-title":"Basic Methods","year":"1999","author":"Oral Health Surveys","key":"e_1_2_6_8_1"},{"key":"e_1_2_6_9_1","first-page":"1","article-title":"Analysis of polymorphism at site \u2010174 G\/C of interleukin\u20106 promoter region in multiple myeloma","volume":"1","author":"Duch CR","year":"2007","journal-title":"Braz J Med Biol Res"},{"doi-asserted-by":"publisher","key":"e_1_2_6_10_1","DOI":"10.1210\/jc.2004-0355"},{"doi-asserted-by":"publisher","key":"e_1_2_6_11_1","DOI":"10.1007\/s00125-004-1623-0"},{"doi-asserted-by":"publisher","key":"e_1_2_6_12_1","DOI":"10.1111\/j.1600-051X.2007.01067.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_13_1","DOI":"10.1902\/jop.2008.070453"},{"doi-asserted-by":"publisher","key":"e_1_2_6_14_1","DOI":"10.1111\/j.1600-051X.2008.01344.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_15_1","DOI":"10.1111\/j.1600-0757.2010.00371.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_16_1","DOI":"10.1177\/154405910508401211"},{"doi-asserted-by":"publisher","key":"e_1_2_6_17_1","DOI":"10.1902\/jop.2006.050315"},{"doi-asserted-by":"publisher","key":"e_1_2_6_18_1","DOI":"10.1034\/j.1600-051X.2003.20016.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_19_1","DOI":"10.1177\/154405910708600505"},{"doi-asserted-by":"publisher","key":"e_1_2_6_20_1","DOI":"10.1902\/jop.2009.080561"},{"doi-asserted-by":"publisher","key":"e_1_2_6_21_1","DOI":"10.1111\/j.1365-2249.2007.03327.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_22_1","DOI":"10.1902\/jop.2004.75.1.30"},{"doi-asserted-by":"publisher","key":"e_1_2_6_23_1","DOI":"10.1902\/jop.2006.050058"},{"doi-asserted-by":"publisher","key":"e_1_2_6_24_1","DOI":"10.2337\/diabetes.52.7.1872"},{"doi-asserted-by":"publisher","key":"e_1_2_6_25_1","DOI":"10.2337\/diabetes.52.2.558"},{"doi-asserted-by":"publisher","key":"e_1_2_6_26_1","DOI":"10.1194\/jlr.P700033-JLR200"},{"doi-asserted-by":"publisher","key":"e_1_2_6_27_1","DOI":"10.2337\/db06-0600"},{"unstructured":"MoreiraPR LimaPM SathlerKOet al.Interleukin\u20106 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals[cited 18 Jun 2016]. Available from:http:\/\/asia.ensembl.org\/Homo_sapiens\/Variation","key":"e_1_2_6_28_1"},{"doi-asserted-by":"publisher","key":"e_1_2_6_29_1","DOI":"10.1016\/j.imbio.2012.12.001"},{"doi-asserted-by":"publisher","key":"e_1_2_6_30_1","DOI":"10.1111\/j.1601-0825.2010.01736.x"},{"doi-asserted-by":"publisher","key":"e_1_2_6_31_1","DOI":"10.4103\/2277-9175.175904"},{"key":"e_1_2_6_32_1","first-page":"60","article-title":"Interleukin\u20106 (IL\u20106)\u2010597 A\/G (rs1800797) & \u2010174 G\/C (rs1800795) gene polymorphisms in type 2 diabetes","volume":"140","author":"Saxena M","year":"2014","journal-title":"Indian J Med Res"},{"doi-asserted-by":"publisher","key":"e_1_2_6_33_1","DOI":"10.1038\/oby.2005.92"},{"key":"e_1_2_6_34_1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00439-003-0912-x","article-title":"The interleukin\u20106 (\u2013174) G\/C promoter polymorphism is associated with type\u20102 diabetes mellitus in Native Americans and Caucasians","volume":"112","author":"Vozarova B","year":"2003","journal-title":"Hum Genet"}],"container-title":["Journal of Investigative and Clinical Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjicd.12230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjicd.12230","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jicd.12230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:09:38Z","timestamp":1696280978000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jicd.12230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,21]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jicd.12230"],"URL":"https:\/\/doi.org\/10.1111\/jicd.12230","archive":["Portico"],"relation":{},"ISSN":["2041-1618","2041-1626"],"issn-type":[{"type":"print","value":"2041-1618"},{"type":"electronic","value":"2041-1626"}],"subject":[],"published":{"date-parts":[[2016,7,21]]},"article-number":"e12230"}}