{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T04:26:13Z","timestamp":1783052773586,"version":"3.54.6"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University Research Grant","award":["RG\/2013\/08\/D"],"award-info":[{"award-number":["RG\/2013\/08\/D"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>) is a common, chronic inflammatory disease of the oral mucosa. Although several studies have shown the efficacy of different treatment modalities, a definitive cure has not yet been established. The present trial compares the effectiveness of topically\u2010applied clobetasol and tacrolimus in the symptomatic management of <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, comparative, double\u2010blind study with 68 patients (43 females, 25 males; mean age: 46.76\u00a0years) was undertaken. Patients were randomly divided into two groups of 34 patients each to receive topical tacrolimus 0.1% cream or clobetasol propionate 0.05% cream for 3\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3\u00a0weeks of treatment, the mean pain score dropped by 1.59 (right) and 1.53 (left) in the tacrolimus group, while in clobetasol group these values were 0.94 and 0.85, respectively. The mean scores for clinical appearance reduced by 1.18 (right) and 1.0 (left) in the tacrolimus group compared with a reduction of 0.5 and 0.26, respectively, in the clobetasol group. These reductions were statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that tacrolimus 0.1% cream is an effective alternative to topical steroid and can be considered a first\u2010line therapy in <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>. However, further studies are needed to confirm the effectiveness of this treatment before it is recommended for use in clinical practice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12237","type":"journal-article","created":{"date-parts":[[2016,9,16]],"date-time":"2016-09-16T04:27:08Z","timestamp":1474000028000},"source":"Crossref","is-referenced-by-count":36,"title":["Comparison of topical tacrolimus and clobetasol in the management of symptomatic oral lichen planus: A double\u2010blinded, randomized clinical trial in Sri Lanka"],"prefix":"10.1111","volume":"8","author":[{"given":"Pilana Vithanage Kalani Shihanika","family":"Hettiarachchi","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Periodontology Faculty of Dental Sciences University of Peradeniya  Peradeniya Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruvini Manjula","family":"Hettiarachchi","sequence":"additional","affiliation":[{"name":"Center for Applied Health 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