{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:34:11Z","timestamp":1761676451648,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,4]],"date-time":"2017-01-04T00:00:00Z","timestamp":1483488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Canadian Association of Oral and Maxillofacial Surgeons"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to profile the expression of human kallikrein (<jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content>)\u2010related peptidases (<jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content>) in odontogenic lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Paraffin\u2010embedded, formalin\u2010fixed, non\u2010odontogenic (control) and odontogenic lesions were stained for <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> using a standard immunohistochemical technique. The intensity and proportion of epithelial cells stained was scored. Reverse transcription\u2010polymerase chain reaction was utilized to evaluate <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 1\u201015 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> expression in ameloblastomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 3, 4, 9, 11, and 14 were present in all lesions. <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 3 staining was increased in ameloblastomas and keratocystic odontogenic tumors. <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 5 was present only in Keratocystic odontogenic tumor. <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 6 was significantly higher in ameloblastomas than in other lesions. For <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 7, keratocystic odontogenic tumors and nasopalatine duct cysts were significantly different. <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 6, 8, 10, 11, and 13 were significantly higher in ameloblastomas than in other lesions. <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 9 was increased in keratocystic odontogenic tumors and dentigerous cysts. The expression of <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 1, 4, 7, 8, 10, and 12 <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> was found in ameloblastomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggested that <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 6, 8, 10, and 13 could be involved in the progression of ameloblastomas. <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> 10 could have a greater role in odontogenic lesions, rather than non\u2010odontogenic lesions. Future studies aim to define the specific roles of <jats:styled-content style=\"fixed-case\">KLK<\/jats:styled-content> cascades in odontogenic lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12256","type":"journal-article","created":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T04:46:50Z","timestamp":1483591610000},"source":"Crossref","is-referenced-by-count":1,"title":["Kallikrein\u2010related peptidase expression in odontogenic cysts and tumors: An immunohistochemical comparative study"],"prefix":"10.1111","volume":"8","author":[{"given":"Mark Roger","family":"Darling","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Woodford","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl Kevin","family":"Cuddy","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Jackson\u2010Boeters","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alyssa","family":"Hayter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeyanth","family":"Inkaran","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleftherios P.","family":"Diamandis","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Mount Sinai Hospital  Toronto Ontario Canada"},{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zia","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Western Ontario  London Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.02.023"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.257.2.5"},{"key":"e_1_2_7_4_1","first-page":"4658","article-title":"Quantitation of prostate\u2010specific antigen in serum by a sensitive enzyme immunoassay","volume":"40","author":"Kuriyama M","year":"1980","journal-title":"Cancer Res"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2351"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2008.02.012"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2014-0123"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00495.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-0607"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2011.00834.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2003.017657"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00291.x"},{"volume-title":"Oral and Maxillofacial Pathology","year":"2009","author":"Neville B","key":"e_1_2_7_13_1"},{"volume-title":"World Health Organization Classification of Tumours. 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