{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:27:51Z","timestamp":1790116071058,"version":"4.0.1"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to assess the periodontal status of individuals and the presence of red complex microorganisms (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>), such as <jats:italic>Treponema denticola<\/jats:italic> (<jats:italic>Td<\/jats:italic>), <jats:italic>Porphyromonas gingivalis<\/jats:italic>, and <jats:italic>Tannerella forsythia<\/jats:italic> in the subgingival tissues of periodontitis patients before and after the application of 4% mangostana gel (<jats:italic>Garcinia mangostana<\/jats:italic> [<jats:italic><jats:styled-content style=\"fixed-case\">MGA<\/jats:styled-content><\/jats:italic>]) as an adjunct to scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010five patients (<jats:italic><jats:styled-content style=\"fixed-case\">MGA<\/jats:styled-content><\/jats:italic> group) were treated with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>, and the subgingival application of mangostana gel was used as local drug delivery. Twenty\u2010five patients (placebo group) were treated with <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> and placebo gel. Clinical parameters were recorded, and the presence of <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> was assessed at baseline and at the third month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical parameters, such as probing pocket depth, clinical attachment level, bleeding index, plaque index, and <jats:italic>Td<\/jats:italic>, were significantly reduced in the <jats:italic><jats:styled-content style=\"fixed-case\">MGA<\/jats:styled-content><\/jats:italic> group compared to the placebo group from baseline to the third month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a significant improvement in the periodontal status with a reduction in <jats:italic>Td<\/jats:italic> with the application of mangostana gel in periodontal pockets. In the near future, 4% mangostana gel can be used as an adjunct to <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> to provide a new dimension to periodontal therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12262","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T05:25:41Z","timestamp":1490073941000},"source":"Crossref","is-referenced-by-count":15,"title":["Clinical and microbiological efficacy of 4% <i>Garcinia mangostana<\/i> L. pericarp gel as local drug delivery in the treatment of chronic periodontitis: A randomized, controlled clinical trial"],"prefix":"10.1111","volume":"8","author":[{"given":"Jaideep","family":"Mahendra","sequence":"first","affiliation":[{"name":"Department of Periodontology Meenakshi Ammal Dental College Meenakshi Academy of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Little","family":"Mahendra","sequence":"additional","affiliation":[{"name":"Department of Periodontics Annamalai University  Chidambaram India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadharshini","family":"Svedha","sequence":"additional","affiliation":[{"name":"Department of Periodontology Meenakshi Ammal Dental College Meenakshi Academy of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandhya","family":"Cherukuri","sequence":"additional","affiliation":[{"name":"Department of Periodontology Meenakshi Ammal Dental College Meenakshi Academy of Higher Education and Research  Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios E.","family":"Romanos","sequence":"additional","affiliation":[{"name":"Department Of Periodontology Stony Brook University  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.322"},{"key":"e_1_2_6_3_1","first-page":"301","volume-title":"Fruits of Warm Climates","author":"Morton JF","year":"1987"},{"key":"e_1_2_6_4_1","volume-title":"Thai Medicinal Plants Recommended for Primary Health Care System","author":"Fansworth NR","year":"1992"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(96)00273-8"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2008.07.007"},{"key":"e_1_2_6_7_1","first-page":"257","article-title":"Pharmacological profile of mangostin and its derivatives","volume":"239","author":"Shankaranarayan D","year":"1979","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_6_8_1","first-page":"399","article-title":"Antibacterial activities of extracts from Garcinia mangostana pericarps on methicillin\u2010resistant Staphylococcus aureus and Enterococcus species","volume":"16","author":"Phongpaichit S","year":"1994","journal-title":"J Sci Technol"},{"key":"e_1_2_6_9_1","author":"Hasegawa H","year":"1996","journal-title":"Jpn Kokai Tokkyo Koho, JP"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_6_11_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2007.12.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.13.3021"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2448875"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2000.0087"},{"key":"e_1_2_6_17_1","first-page":"38","volume-title":"Proceedings of the Second European Workshop on Periodontology","author":"Mombelli A","year":"1997"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.11.1143"},{"key":"e_1_2_6_19_1","first-page":"461","article-title":"Evaluation of efficacy of enamel matrix derivative in treatment of infrabony defects","volume":"25","author":"Francetti L","year":"2005","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1996.tb00072.x"},{"key":"e_1_2_6_21_1","first-page":"24","article-title":"Perez\u2010Rojas. 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