{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:54:13Z","timestamp":1790510053482,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to systematically review the efficacy of photodynamic therapy (<jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>) in the management of oral potentially\u2010malignant disorders (<jats:styled-content style=\"fixed-case\">PMDS<\/jats:styled-content>) and head and neck squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From 1985 to 2015, PubMed\/Medline, Google Scholar, <jats:styled-content style=\"fixed-case\">EMBASE<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">ISI<\/jats:styled-content> Web of Knowledge were searched using different combinations of the following key words: <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content>, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content>. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six studies were included in the present study. The number of patients ranged from 2 to 147, with a mean age of 50\u201067\u00a0years. The reported numbers of <jats:styled-content style=\"fixed-case\">PMDS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content> ranged between 5 and 225. Photosensitizers used were aminolevulinic acid, meta\u2010tetrahydroxyphenylchlorin, Foscan, hematoporphyrin derivatives, Photofrin, Photosan, and chlorine\u2010e6. Laser wavelength, power density, irradiation duration were 585\u2010652\u00a0nm, 50\u2010500\u00a0mW\/cm<jats:sup>2<\/jats:sup>, and 1\u2010143\u00a0minutes, respectively. Complete, partial, and no response to <jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> was found in 22.58%\u2010100%, 4%\u201066%, and 0%\u201038.70% of <jats:styled-content style=\"fixed-case\">PMDS<\/jats:styled-content>, respectively, and 16%\u2010100% of complete response in <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content> patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PDT<\/jats:styled-content> is effective in the management of <jats:styled-content style=\"fixed-case\">PMDS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HNSCC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12270","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T06:22:31Z","timestamp":1494224551000},"source":"Crossref","is-referenced-by-count":36,"title":["Photodynamic treatment outcomes of potentially\u2010malignant lesions and malignancies of the head and neck region: A systematic review"],"prefix":"10.1111","volume":"9","author":[{"given":"Shailesh M.","family":"Gondivkar","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology Government Dental College and Hospital  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-7694","authenticated-orcid":false,"given":"Amol Ramchandra","family":"Gadbail","sequence":"additional","affiliation":[{"name":"Department of Dentistry Indira Gandhi Government Medical College and Hospital  Nagpur Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjari G.","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Mahatma Gandhi Vidyamandir's Karmaveer Bhausaheb Hirey Dental College and Hospital  Nashik Maharashtra 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