{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:46:10Z","timestamp":1782294370374,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Borinic acid quinoline esters are a recently\u2010identified class of new antibacterial and anti\u2010inflammatory compounds known to inhibit osteoclastic bone resorption. They have proposed to have osteostimulative properties by causing osteoblast differentiation in vivo and in vitro. The purpose of this double\u2010masked, randomized, controlled clinical trial was to evaluate the effects of the subgingival delivery of boric acid gel as an adjunct to scaling and root planing (<jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content>) on clinical and radiographic parameters, and compare this method with SRP plus placebo gel alone in chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010nine systemically\u2010healthy patients with <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> were included in the present study. They were divided into two groups: (a) <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> + 0.75% boric acid gel (BA group); and (b) <jats:styled-content style=\"fixed-case\">SRP<\/jats:styled-content> + placebo gel (placebo group). At baseline, 3 and 6\u00a0months after treatment, clinical measurements, including plaque index, modified sulcus bleeding index, probing depth (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>), clinical attachment level (<jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content>), intrabony defect depth, and percentage change in radiographic defect depth reduction (<jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content>%) as radiographic parameters were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> reduction and mean <jats:styled-content style=\"fixed-case\">CAL<\/jats:styled-content> gain were greater in the <jats:styled-content style=\"fixed-case\">BA<\/jats:styled-content> group than the placebo group at 3 and 6\u00a0months. A significantly greater mean percentage of radiographic <jats:styled-content style=\"fixed-case\">DDR<\/jats:styled-content>% was found in the BA group (36.97\u00b13.47%) compared to the placebo group (2.88\u00b10.89%) after 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BA as an adjunct to SRP can provide a new insight into therapeutic strategies for the management of CP, but further clinical evaluations are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12271","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T07:22:42Z","timestamp":1493968962000},"source":"Crossref","is-referenced-by-count":23,"title":["Clinical efficacy of subgingivally\u2010delivered 0.75% boric acid gel as an adjunct to mechanotherapy in chronic periodontitis: A randomized, controlled clinical trial"],"prefix":"10.1111","volume":"9","author":[{"given":"Dharmendra","family":"Kanoriya","sequence":"first","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibhuti","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bangalore Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-9519","authenticated-orcid":false,"given":"Avani R.","family":"Pradeep","sequence":"additional","affiliation":[{"name":"Department of Periodontology Government Dental 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