{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:38:15Z","timestamp":1753879095468,"version":"3.41.2"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T00:00:00Z","timestamp":1507334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of the present study was to develop techniques to evaluate and quantify the primary components of dental medicament paste mixtures for root canal treatment, and to evaluate if degradation of the primary components occurred during storage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The first part of the study developed a mass spectrometry (<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>) method for determination of best recovery process. For this process, analytical grades of triamcinolone acetonide, clindamycin <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>l, and doxycycline hyclate were sourced and analyzed. This was followed by solid\u2010phase extraction (<jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content>) and an analysis of active components in dental pastes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By utilizing the targeted analytical properties of multiple reaction monitoring <jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> methods, coupled with <jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content> technique, the active components of endodontic dental pastes could be quantified and compared. The developed methods showed consistency over multiple runs, with a high level of reproducibility. None of the active components of the tested pastes degraded over the periods of product life tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The inactivation or destruction of any of the primary components of endodontic medicaments in storage, or when mixed with other pastes, could affect treatment outcomes. The present study provides a reliable technique for the analysis of the active components of root canal medicaments.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12294","type":"journal-article","created":{"date-parts":[[2017,10,7]],"date-time":"2017-10-07T06:52:40Z","timestamp":1507359160000},"source":"Crossref","is-referenced-by-count":1,"title":["Development of techniques for determination of primary components of dental medicament paste mixtures for root canal treatment"],"prefix":"10.1111","volume":"9","author":[{"given":"James","family":"Jarrett","sequence":"first","affiliation":[{"name":"School of Natural Sciences Griffith University  Nathan Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"White","sequence":"additional","affiliation":[{"name":"School of Natural Sciences Griffith University  Nathan Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah 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