{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:37:21Z","timestamp":1775885841252,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T00:00:00Z","timestamp":1510185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>The action of statins in stimulating bone formation and having other pleiotropic effects, such as anti\u2010inflammatory and immunomodulatory effects, has justified their use as an adjunct to scaling and root planing (SRP<\/jats:styled-content>) in the treatment of chronic periodontitis (CP<\/jats:styled-content>). The aim of the present study was to evaluate the efficacy of statin delivery as an adjunct to SRP<\/jats:styled-content> in the treatment of CP<\/jats:styled-content>. Electronic searches were conducted using the following databases: MEDLINE<\/jats:styled-content>, EMBASE<\/jats:styled-content>, Cochrane Central Register of Controlled Trials, and Cochrane Oral Health Group Trials Register, up until July 2017. The primary outcome was probing depth (PD<\/jats:styled-content>), while the secondary outcomes were changes in clinical attachment level (CAL<\/jats:styled-content>) and bone defect (BD<\/jats:styled-content>) fill. Eleven studies were included, and all showed significant PD<\/jats:styled-content> reduction, CAL<\/jats:styled-content> gain, and BD<\/jats:styled-content> fill with adjunctive statin delivery compared to SRP<\/jats:styled-content> alone. The meta\u2010analysis showed significant improvement in periodontal parameters for atorvastatin (PD<\/jats:styled-content>: weighted mean difference [WMD<\/jats:styled-content>]\u00a0=\u00a0\u22121.84, \u22122.56 to \u22121.12, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001; CAL<\/jats:styled-content>: WMD<\/jats:styled-content>\u00a0=\u00a0\u22122.31, \u22123.58 to \u22121.03, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001; BD<\/jats:styled-content> fill: WMD<\/jats:styled-content>\u00a0=\u00a02.66, \u22123.92 to \u22121.39, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), simvastatin (PD<\/jats:styled-content>: WMD<\/jats:styled-content>\u00a0=\u00a0\u22121.91, \u22122.27 to \u22121.55, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001; CAL<\/jats:styled-content>: WMD<\/jats:styled-content>\u00a0=\u00a0\u22121.91, \u22122.27 to \u22121.55, P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>.001; BD<\/jats:styled-content>: WMD<\/jats:styled-content>\u00a0=\u00a0\u22121.52, \u22122.20 to \u22120.85, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001), and rosuvastatin (PD<\/jats:styled-content>: WMD<\/jats:styled-content>\u00a0=\u00a0\u22120.94, \u22121.32 to \u22120.55, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001; CAL<\/jats:styled-content>: WMD<\/jats:styled-content>\u00a0=\u00a0\u22121.00, \u22121.41 to \u22120.60, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001; BD<\/jats:styled-content> fill: WMD<\/jats:styled-content>\u00a0=\u00a0\u22121.30, \u22121.80 to \u22120.79, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>.001). Adjunctive statin delivery appears to be effective in reducing PD<\/jats:styled-content>, CAL<\/jats:styled-content> gain, and BD<\/jats:styled-content> fill in CP<\/jats:styled-content>, and therefore, these drugs could be a promising therapeutic option for periodontal regeneration in future.<\/jats:p>","DOI":"10.1111\/jicd.12304","type":"journal-article","created":{"date-parts":[[2017,11,9]],"date-time":"2017-11-09T08:58:44Z","timestamp":1510217924000},"source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of statin delivery as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A meta\u2010analysis"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9618-8818","authenticated-orcid":false,"given":"Zohaib","family":"Akram","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Ziauddin University Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fahim","family":"Vohra","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Sciences College of Dentistry, King Saud University Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fawad","family":"Javed","sequence":"additional","affiliation":[{"name":"Department of General Dentistry Eastman Institute for Oral Health University of Rochester Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12392"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.322"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.338"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.280102.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s2.4.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.120040"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13147"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2015.06.010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1089\/pho.2015.4076"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2016.09.004"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-016-2086-5"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2016.11.008"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.140631"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110716"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.12.002"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2014.02.009"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60367-5"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.02.019"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.21.4.0403"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.03242.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.37.2.h606137vj3826v61"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-152-11-201006010-00232"},{"key":"e_1_2_5_25_1","unstructured":"HigginsJPT GreenS eds.Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. 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