{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:47:56Z","timestamp":1790912876726,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T00:00:00Z","timestamp":1511913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest & Clin Dent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Hepatocyte growth factor (HGF<\/jats:styled-content>) is a multifunctional cytokine with a wide range of actions, and plays a role in periodontal disease (PD<\/jats:styled-content>) progression. Smoking significantly increases the risk for PD<\/jats:styled-content> progression. Thus, aim of the present study was to estimate salivary HGF<\/jats:styled-content> levels of non\u2010smokers and smokers with chronic periodontitis (CP<\/jats:styled-content>) and to compare its levels before and after therapy.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 75 participants were recruited and divided into three groups: group 1 included 25 healthy participants, group 2 included 25 non\u2010smokers with CP<\/jats:styled-content>, and group 3 included 25 smokers with CP<\/jats:styled-content>. Salivary HGF<\/jats:styled-content> levels were estimated by enzyme\u2010linked immunosorbent assay and correlated with clinical parameters before and after treatment.<\/jats:p><\/jats:sec>Results<\/jats:title>Salivary HGF<\/jats:styled-content> levels of non\u2010smokers and smokers with CP<\/jats:styled-content> were significantly higher than the control group. There was a significant reduction in salivary HGF<\/jats:styled-content> in smokers and non\u2010smokers with CP<\/jats:styled-content> after non\u2010surgical periodontal therapy (NSPT<\/jats:styled-content>).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Salivary HGF<\/jats:styled-content> levels positively correlated with PD<\/jats:styled-content> progression and smoking status. A significant reduction in HGF<\/jats:styled-content> levels was seen after NSPT<\/jats:styled-content>. Thus, within limits, it can be suggested that HGF<\/jats:styled-content> plays a role in PD<\/jats:styled-content> progression and can be used as a diagnostic biomarker to detect disease activity. Salivary HGF<\/jats:styled-content> levels could also be useful to monitor response to periodontal therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12306","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:27:10Z","timestamp":1511976430000},"source":"Crossref","is-referenced-by-count":9,"title":["Comparative evaluation of salivary hepatocyte growth factor in smokers and non\u2010smokers with chronic periodontitis"],"prefix":"10.1111","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9991-3269","authenticated-orcid":false,"given":"Sanjeela","family":"Guru","sequence":"first","affiliation":[{"name":"Department of Periodontology Vydehi Institute of Dental Sciences and Research Centre Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheena Elizabeth","family":"Sam","sequence":"additional","affiliation":[{"name":"Department of Periodontology Vydehi Institute of Dental Sciences and Research Centre Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanya","family":"Rajan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Vydehi Institute of Dental Sciences and Research Centre Bangalore India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyam","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Periodontology Vydehi Institute of Dental Sciences and Research Centre Bangalore 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