{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T21:23:15Z","timestamp":1772659395676,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007859","name":"Graduate School, Chiang Mai University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007859","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to investigate the prevalence of hepatitis C virus (<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>) infection and evaluate liver enzyme levels in patients from upper northern Thailand with oral lichen planus (<jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study of 101 patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> and 101 patients without <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> was conducted. Peripheral blood was taken from each patient and screened for anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibody using immunochromatography. Positive samples were further confirmed using chemiluminescent microparticle immunoassay (<jats:styled-content style=\"fixed-case\">CMIA<\/jats:styled-content>) and reverse transcription\u2010polymerase chain reaction. In addition, liver enzyme levels, alanine transaminase, aspartate transaminase, and alkaline phosphatase were evaluated using spectrophotometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Immunochromatography and <jats:styled-content style=\"fixed-case\">CMIA<\/jats:styled-content> revealed that nine patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> (8.9%) were positive for anti\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> antibodies, whereas only one patient without <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> was <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> positive (odds ratio\u00a0=\u00a09.78). All patients who were <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> positive had significantly higher liver enzyme levels than patients who were <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of the present study indicated that <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> in certain patients was significantly associated with <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. This could warrant screening for <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients with <jats:styled-content style=\"fixed-case\">OLP<\/jats:styled-content> in Thailand.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12316","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T07:16:37Z","timestamp":1516259797000},"source":"Crossref","is-referenced-by-count":12,"title":["Association between hepatitis C infection in Thai patients with oral lichen planus: A case\u2010control study"],"prefix":"10.1111","volume":"9","author":[{"given":"Trin","family":"Manomaivat","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Faculty of Dentistry Chiang Mai University  Chiang Mai Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surawut","family":"Pongsiriwet","sequence":"additional","affiliation":[{"name":"Department of Oral Biology and Diagnostic Sciences Faculty of 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