{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:23:55Z","timestamp":1789950235084,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Invest &amp; Clin Dent"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to evaluate and correlate the levels of interleukin\u201034 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201034) in gingival crevicular fluid (<jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>) and plasma in chronic periodontitis (<jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>) patients with and without type\u20102 diabetes mellitus (<jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 175 patients were divided into five groups: (a) group I had 35 periodontally\u2010healthy patients; (b) group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> had 35 chronic gingivitis patients; (c) group <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> had 35 <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> patients without type\u20102 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>; (d) group <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> had 35 <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content> patients with type\u20102 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>; and (e) group V had 35 type\u20102 <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content> patients without <jats:styled-content style=\"fixed-case\">CP<\/jats:styled-content>. The <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and plasma levels of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201034 were quantified using enzyme\u2010linked immunosorbent assay. Clinical and systemic parameters, such as gingival index, probing pocket depth, clinical attachment loss, and glycated hemoglobin levels, were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201034 concentration in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and plasma was highest for group <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, followed by groups <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, V, and <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, and lowest in group I. The difference between them was statistically significant (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>.05). There was a positive correlation between <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201034 concentration in <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and plasma in the study groups, with the exception of group I, for which there was a negative correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201034 can be considered a possible <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and plasma inflammatory biomarker of periodontal disease progression and <jats:styled-content style=\"fixed-case\">DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jicd.12317","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T04:13:01Z","timestamp":1516335181000},"source":"Crossref","is-referenced-by-count":16,"title":["Interleukin\u201034 levels in gingival crevicular fluid and plasma in periodontal health and disease with and without type\u20102 diabetes mellitus"],"prefix":"10.1111","volume":"9","author":[{"given":"C. N.","family":"Guruprasad","sequence":"first","affiliation":[{"name":"Department of Periodontology Government Dental College and Research Institute  Bengaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7217-9519","authenticated-orcid":false,"given":"A. 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